Foreign matter identification from solid dosage forms

A Step Toward Development of Printable Dosage Forms for Poorly Soluble Drugs

“…SEM–EDX is a widely used method for elemental analysis in various other fields . In pharmaceutical field, it has been used for monitoring inorganic elements during coating of tablets and for foreign matter identification of solid dosage forms . By scanning the electron beam across the sample surface and detecting the emitted X‐rays from each pixel, the elemental distribution can be point located and related to the SEM image.…”

“…15,16 In pharmaceutical field, it has been used for monitoring inorganic elements during coating of tablets 17 and for foreign matter identification of solid dosage forms. 18 By scanning the electron beam across the sample surface and detecting the emitted X-rays from each pixel, the elemental distribution can be point located and related to the SEM image. Beam energy of 20 kV was used to yield sufficient X-ray signal for mapping, and the resulting mapping images were processed as TruMaps.…”

Mass Spectrometry Imaging in Drug Development

“…The most attractive quality of SIMS imaging, and the one that justifies the investment in the costly equipment and laborious sample preparation it requires, is that it can achieve very high spatial resolutions. This high spatial resolution makes SIMS imaging a powerful tool for pharmaceutical R&D, pharmaceutical formulation, and manufacturers, − but the technical challenges it presents and its limited sensitivity mean that it is most useful in specific and focused investigations rather than being a general purpose MSI approach.…”