Forensic Science

Brettell, Thomas A.; Inman, Keith; Rudin, Norah; Saferstein, Richard

doi:10.1021/ac010399p

Cited by 18 publications

(10 citation statements)

References 232 publications

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“…in some fields (i.e., forensic [3], biological [4], clinical analysis, etc.) the sample volume available can be lower than 1 ml; 2. the optimization of new coupling techniques, such as Capillary Electrophoresis (CE) [5] or other chromatographies coupled to ICP-AES (or ICP-MS), involves the use of a low sample consumption system;.…”

Section: Importance Of the Analysis Of Microsamplesmentioning

confidence: 99%

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Todolı́

Mermet²

2006

Spectrochimica Acta Part B: Atomic Spectroscopy

133

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Section: Importance Of the Analysis Of Microsamplesmentioning

confidence: 99%

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Todolı́

Mermet²

2006

Spectrochimica Acta Part B: Atomic Spectroscopy

133

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“…Cannabinoids are usually detected using gas chromatography [ 6 – 8 ] or high-performance liquid chromatography, coupled to electrochemical detection [ 9 – 11 ]. However, given that electrochemical sensors are known for their high reliability and speed of response, their low cost and their compatibility for miniaturisation [ 12 ], they offer an attractive portable alternative [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Absorptive stripping voltammetry for cannabis detection

Nissim

Compton

2015

Chemistry Central Journal

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BackgroundGiven that Δ9-tetrahydrocannabinol, the active constituent of cannabis, has been shown to greatly reduce driving ability, thus being linked to many drug driving accidents, its reliable detection is of great importance.ResultsAn optimised carbon paste electrode, fabricated from graphite powder and mineral oil, is utilised for the sensitive detection of Δ9-tetrahydrocannabinol (THC) in both aqueous solutions of pH 10.0 and in synthetic saliva solutions. “Absorptive Stripping Voltammetry” is exploited to that effect and the paste is used to pre-concentrate the carbon paste electrode with the target molecule. Practical limits of detection of 0.50 μM and 0.10 μM are determined for THC in stationary and stirred aqueous borate buffer solutions, respectively. Theoretical limits of detection are also calculated; values of 0.48 nM and 0.41 nM are determined for stationary and stirred THC aqueous borate buffer solutions, respectively. THC concentrations as low as 0.50 μM are detected in synthetic saliva solutions. The sensitivity of the sensor was 0.12 μA μM−1, 0.84 μA μM−1 and 0.067 μA μM−1 for the stationary buffer, the stirred buffer and the saliva matrix, respectively.Conclusions“Absorptive Stripping Voltammetry” can be reliably applied to the detection of Δ9-tetrahydrocannabinol, after suitable optimisation of the assay. Usefully low practical limits of detection can be achieved.

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“…As recently discussed, the ability to separate amphetamine and methamphetamine from analogous compounds is important in clinical, pharmaceutical and forensic applications [2,5,6,22]. The chip-based system was thus first tested for achiral analysis.…”

Section: Mekc Separation Of Labeled Drugsmentioning

confidence: 99%

“…Several analytical techniques, including gas and liquid chromatography, have been presented for achiral and chiral separations of amphetamine and related compounds [2]. Recently, electrophoretic techniques, such as capillary zone electrophoresis (CZE), electrokinetic capillary chromatography (EKC) and micellar electrokinetic capillary chromatography (MEKC) have been employed [1±10].…”

Section: Introductionmentioning

confidence: 99%

On-chip chiral and achiral separation of amphetamine and related compounds labeled with 4-fluoro-7-nitrobenzofurazane

et al. 2000

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Amphetamine and analogous compounds have been labeled with 4-fluoro-7-nitrobenzofurazane and analyzed on a microfabricated chip. Separation of norephedrine, ephedrine, cathinone, pseudoephedrine, methcathinone, amphetamine and methamphetamine is demonstrated using micellar electrokinetic capillary chromatography (MEKC) and laser-induced fluorescence (LIF) detection. Chiral separations of individual drugs were studied using neutral and negatively charged cyclodextrins (CDs) with and without the addition of an organic modifier and/or sodium dodecyl sulfate (SDS). The best results were obtained using a highly sulfated gamma-CD (HS-gamm-CD) in combination with a low concentration of SDS. To obtain complete separation of a mixture of (+/-)-norephedrine, (+/-)ephedrine, (+/-)-pseudoephedrine, (+/-)-methcathinone, (+/-)-amphetamine and (+/-)-methamphetamine it was necessary to add a small amount (1.5 mM) of SDS to the separation buffer. Optimized chiral separation was achieved within 7 min using an S-folded separation channel, a separation voltage of 8 kV and a buffer consisting of 50 mM phosphate (pH 7.35), 10 mM HS-gamma-CD and 1.5 mM SDS.

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Forensic Science

Cited by 18 publications

References 232 publications

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS

Absorptive stripping voltammetry for cannabis detection

On-chip chiral and achiral separation of amphetamine and related compounds labeled with 4-fluoro-7-nitrobenzofurazane

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