Forensic toxicological implication of acute fatal poisoning cases due to benfuracarb ingestion

Lee, S. K.; Ameno, Kiyoshi; Yang, Ja-Yeol; In, Sangwhan; Kim, K. U.; Kwon, Tae J.; Yoo, Young-Chan; Kubota, Takako; Ameno, Setsuko; Ijiri, Iwao

doi:10.1007/s004140050247

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…Insecticide poisonings are nowadays mainly a problem in developing countries [6,7,8,9], whereas OP intoxication in highly developed countries generally is less often due to suicidal attempts [10] and seem to be quite uncommon [3,8,11,12,13,14,15]. On the contrary, poisoning with pesticides like paraquat or diquat are described more often [16].…”

Section: Discussionmentioning

confidence: 99%

Fatal intoxication with omethoate

et al. 2002

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A case of suicide with the insecticide omethoate is reported. An 18-year-old apprentice gardener had ingested an unknown amount of omethoate. His body was found in his room lying in the storage space under his bed. The autopsy first showed multiple superficial incisions in the skin of his wrists, furthermore hemorrhagic pulmonary oedema, dilation of the right cardiac ventricle and oedema of the brain. The gastric mucosa was swollen and showed a dark brownish colour. An intensive, chemical-like smell rose from the corpse and organs. Toxicological analysis detected omethoate in cardiac blood (208 micro g/ml), urine (225 micro g/ml) and bile (524 micro g/ml), in the liver (341 micro g/ml) and kidneys (505 micro g/ml). In the gastric content the level was 48223 micro g/ml. The amount of the active AChE in peripheral blood serum was reduced to less than 0.2% of the normal level. To our knowledge no case of a fatal suicide by ingestion of omethoate has been reported in literature.

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Section: Discussionmentioning

confidence: 99%

Fatal intoxication with omethoate

et al. 2002

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“…Carbofuran is found to be more persistent and toxic (Iesce et al 2006). It was estimated that death was induced by the combined toxicity of benfuracarb itself and its metabolite carbofuran (Lee et al 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Rare fatal cases due to pesticide have been recently reported (Kenneth et al 1992;Picotte and Perreault 1991;West et al 1997;Kintz et al 1997). Because benfuracarb is widely used and has a high toxicity, there is the possibility of fatal poisoning due to accidental ingestion or for suicidal or homicidal purposes (Lee et al 1999). For the toxicological evaluation of benfuracarb poisoning, benfuracarb and carbofuran must be quantified simultaneously in biological materials because the toxicity of carbofuran (oral LD50 value in rats; 8 mg/kg) is 17 times higher than benfuracarb (oral LD50 value in rats; 138 mg/kg) (Tomlin 1997).…”

Section: Introductionmentioning

confidence: 99%

Mutagenic and cytotoxic activities of benfuracarb insecticide

et al. 2014

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Benfuracarb is a carbamate insecticide used to control insect pests in vegetables and it has anti-acetylcholinesterase activity lower than other carbamates. Cytotoxic effects of benfuracarb were evaluated by using root growth inhibition (EC 50 ), mitotic index (MI), and mitotic phase determinations on the root meristem cells of Allium cepa and mutagenic effects were determined in Salmonella typhymurium Ames test by TA98 and TA100 strains with and without metabolic activation. In Allium test, 1 % DMSO was used as negative control group and 10 ppm MMS was used as positive control group. 75 ppm concentration of benfuracarb was found as EC 50 . In MI and mitotic phases determination study, 37.5, 75 and 150 ppm doses of benfuracarb were used. Dose-dependent cytotoxic activity was found by root growth inhibition and MI studies. It was identified that mitotic inhibition activity of benfuracarb was higher than 10 ppm MMS. In Ames test, mutagenic activity was not observed and over 200 lg/plate of benfuracarb was determined as cytotoxic to S. typhymurium strains. Benfuracarb can be called as ''mitotic inhibitor'' but not called as mutagen.

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“…4). Für den Nachweis von Carbofuran in Nieren, Muskelgewebe und Blut kam zuerst eine rein qualitative Methode zur Anwendung, wobei der Wirkstoff mittels gaschromatographischer Auftrennung gekoppelt an Massenspektrometrie identifiziert wurde (Lee et al, 1999;Ameno et al, 2001). Neben dem Carbofuran wurde dabei auch ein Metabolit sichtbar, der durch «Verseifung», das heisst Hydrolyse der Seitenkette entsteht.…”

Section: Toxikologische Untersuchungenunclassified

Carbofuran-Vergiftung bei wildlebenden Stockenten

Kupper¹,

Baumgartner²,

Ln³

et al. 2007

Schweizer Archiv für Tierheilkunde

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Carbofurane, a pesticide from the group of carbamates, has been employed against soil nematodes on a small meadow at the lake of Lugano, Switzerland. On the next morning, the first cases of death involving a total of 19 mallard ducks (Anas platyrhynchos) have been reported. By inhibiting the enzymatic breakdown of the neurotransmitter acetycholine, carbamates lead to excessive activation of the parasympathicus. In addition, paralysis of skeletal muscles is caused by continued stimulation of neuromuscular junctions. Death may occur by asphyxia. In the present case report, the diagnosis of poisoning could be confirmed by the chemical detection of carbofuran in the stomach, blood, muscle and kidney tissue of the affected mallard ducks.

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Forensic toxicological implication of acute fatal poisoning cases due to benfuracarb ingestion

Cited by 11 publications

References 5 publications

Fatal intoxication with omethoate

Fatal intoxication with omethoate

Mutagenic and cytotoxic activities of benfuracarb insecticide

Carbofuran-Vergiftung bei wildlebenden Stockenten

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