Formalin for haemorrhagic radiation-induced proctitis

Sánchez, Alfredo Hernández; Sánchez, Maria del Pilar Vicente; Jiménez, Marta Ruiz

doi:10.1007/s00384-011-1268-7

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Radiation proctitis is the most common radiotherapy side effect 1 of abdominal and pelvic malignant tumors, such as colorectal cancer, ovarian cancer, prostate cancer and bladder cancer etc. The acute and chronic radiation proctitis incidence is 50%-75% and 5%, respectively 2 . Patients with radiation proctitis mainly suffered from abdominal pain, diarrhea, excretion of mucus or blood and so on.…”

Section: Introductionmentioning

confidence: 99%

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

Gao

You-song

et al. 2020

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose Changrui enema, a traditional Chinese medicine prescription, is used as a supplementary treatment for acute radiation proctitis (ARP). Herein we explored the inhibition effects of Changrui enema on NF-κB and VEGF in ARP mice. Methods A total of 120 C57BL/6 mice were divided randomly into normal mice group, ARP mice group, western medicine enema group (dexamethasone combined with gentamicin), and Changrui enema group. ARP mice were established by pelvic local irradiation. The expression of IL-1β, NF-κB, VEGF, AQP1, AQP3, p-ERK1/2 and p-JNK was determined by immunohistochemistry or western blot. Results The study firstly found that Changrui enema alleviated ARP mice. The expression of IL-1β, NF-κB, VEGF, AQP1 and p-ERK1/2 was increased in ARP mice, and was reserved by Changrui enema. However, the expression of AQP3 and p-JNK was decreased in ARP mice, and was up-regulated by Changrui enema. Conclusions Changrui enema is an effective treatment with fewer side effects for ARP. The mechanism of Changrui enema may be related to the inhibition of inflammation-induced angiogenesis. Changrui enema inhibits IL-1β and NF-κB expression as well as VEGF expression. Interestingly, AQP1 promotes angiogenesis, while AQP3 inhibits inflammation. Changrui enema probably inhibits AQP1 expression by down-regulating p-ERK1/2, and improves AQP3 expression by up-regulating p-JNK.

show abstract

Section: Introductionmentioning

confidence: 99%

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

Gao

You-song

et al. 2020

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Radiation proctitis is a very common complication of pelvic radiotherapy attributed to radiation exposure which typically afflicts quality of life, results in radiotherapy failure and unfavorable prognosis 1,2 . Radiation proctitis is traditionally divided into acute radiation proctitis (ARP) and chronic radiation proctitis (CRP), which are up to 50-75% and 5%, respectively 3 . The mechanism of radiation proctitis is not completely clarified but several signaling pathways have been suggested as part of the pathogenesis of this disease, including inflammatory response 4 , angiogenesis [5][6][7] , immune system 4 , cell adhesion 8 , and extracellular matrix remodeling 9 .…”

mentioning

confidence: 99%

“…The mechanism of radiation proctitis is not completely clarified but several signaling pathways have been suggested as part of the pathogenesis of this disease, including inflammatory response 4 , angiogenesis [5][6][7] , immune system 4 , cell adhesion 8 , and extracellular matrix remodeling 9 . It is characterized by abdominal pain, mucous bloody diarrhea, as well as anal spasm and tenesmus 3 , even intestinal obstruction or perforation.…”

mentioning

confidence: 99%

Novel mechanisms underlying inhibition of inflammation-induced angiogenesis by dexamethasone and gentamicin via PI3K/AKT/NF-κB/VEGF pathways in acute radiation proctitis

You-song

Ding

Gao

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Acute radiation proctitis (ARP) is one of the most common complications of pelvic radiotherapy attributed to radiation exposure. The mechanisms of ARP are related to inflammation, angiogenesis, and so on. In this study we evaluated the effect of dexamethasone (DXM) combined with gentamicin (GM) enema on ARP mice, and explored its possible mechanisms by transcriptome sequencing, western blot and immunohistochemistry. C57BL/6 mice were randomly divided into 3 groups: healthy control group, ARP model group, and DXM + GM enema treatment group. ARP mice were established by using a single 6 MV X-ray dose of 27 Gy pelvic local irradiation. Transcriptome sequencing results showed that 979 genes were co-upregulated and 445 genes were co-downregulated in ARP mice compared to healthy mice. According to gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis, we firstly found that PI3K/AKT/NF-κB/VEGF pathways were mostly correlated with the inflammation-induced angiogenesis in ARP mice. PI3K/AKT pathway leads to the activation of NF-κB, which promotes the transcription of VEGF and Bcl-2. Interestingly, symptoms and pathological changes of ARP mice were ameliorated by DXM + GM enema treatment. DXM + GM enema inhibited inflammation by downregulating NF-κB and upregulating AQP3, as well as inhibited angiogenesis by downregulating VEGF and AQP1 in ARP mice. Moreover, DXM + GM enema induced apoptosis by increasing Bax and suppressing Bcl-2. The novel mechanisms may be related to the downregulation of PI3K/AKT/NF-κB/VEGF pathways.

show abstract

Chronic radiation proctitis: tricks to prevent and treat

Vanneste

Voorde

Ridder

et al. 2015

Int J Colorectal Dis

106

View full text Add to dashboard Cite

ObjectiveThe purpose of this study was to give an overview of the measures used to prevent chronic radiation proctitis (CRP) and to provide an algorithm for the treatment of CRP.MethodsMedical literature databases including PubMed and Medline were screened and critically analyzed for relevance in the scope of our purpose.ResultsCRP is a relatively frequent late side effect (5–20%) and mainly dependent on the dose and volume of irradiated rectum. Radiation treatment (RT) techniques to prevent CRP are constantly improving thanks to image-guided RT and intensity-modulated RT. Also, newer techniques like protons and new devices such as rectum spacers and balloons have been developed to spare rectal structures. Biopsies do not contribute to diagnosing CRP and should be avoided because of the risk of severe rectal wall damage, such as necrosis and fistulas. There is no consensus on the optimal treatment of CRP. A variety of possibilities is available and includes topical and oral agents, hyperbaric oxygen therapy, and endoscopic interventions.ConclusionsCRP has a natural history of improving over time, even without treatment. This is important to take into account when considering these treatments: first be conservative (topical and oral agents) and be aware that invasive treatments can be very toxic.

show abstract

Formalin for haemorrhagic radiation-induced proctitis

Cited by 4 publications

References 0 publications

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF

Novel mechanisms underlying inhibition of inflammation-induced angiogenesis by dexamethasone and gentamicin via PI3K/AKT/NF-κB/VEGF pathways in acute radiation proctitis

Chronic radiation proctitis: tricks to prevent and treat

Contact Info

Product

Resources

About