“…We faced particular problems in the recommendation of a biopsy in patients with indeterminate microcalcifications in a round or oval cluster, according to our criteria H a BI-RADS H 3 lesion. Although LANYI claims that he has never observed a malignancy with round or oval distribution patterns in 153 clusters of microcalcifications (11), the distribution pattern ''round or oval'', particularly in small clusters with a diameter of 5 mm to 10 mm, cannot always be discriminated definitively from small regional/segmental distributions. As lesions in high-risk patients (for definition, see Material and Methods section) have a higher pretest probability for breast cancer per se, we recommend a vacuum core biopsy in these patients.…”