Formation and characterization of quercetin-loaded chitosan oligosaccharide/β-lactoglobulin nanoparticle

Ha, Ho-Kyung; Kim, Jin Wook; Lee, Mee-Ryung; Lee, Won–Jae

doi:10.1016/j.foodres.2013.02.021

Cited by 71 publications

(64 citation statements)

References 38 publications

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“…activity during food storage, processing, and during gastrointestinal digestion [5][6][7]. Ferritin is an attractive nanomaterial for encapsulation and has a well-defined spherical structure with inner and outer diameters of 8 and 12 nm, respectively ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin Gallate (EGCG) Decorating Soybean Seed Ferritin as a Rutin Nanocarrier with Prolonged Release Property in the Gastrointestinal Tract

Yang

Sun

Zhang

et al. 2016

Plant Foods Hum Nutr

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The instability and low bioavailability of polyphenols limit their applications in food industries. In this study, epigallocatechin gallate (EGCG) and soybean seed ferritin deprived of iron (apoSSF) were fabricated as a combined double shell material to encapsulate rutin flavonoid molecules. Firstly, due to the reversible assembly characteristics of phytoferritin, rutin was successfully encapsulated within apoSSF to form a ferritin-rutin complex (FR) with an average molar ratio of 28.2: 1 (rutin/ferritin). The encapsulation efficiency and loading capacity of rutin were 18.80 and 2.98 %, respectively. EGCG was then bound to FR to form FR-EGCG composites (FRE), and the binding number of EGCG was 27.30 ± 0.68 with a binding constant K of (2.65 ± 0.11) × 10(4) M(-1). Furthermore, FRE exhibited improved rutin stability, and displayed prolonged release of rutin in simulated gastrointestinal tract fluid, which may be attributed to the external attachment of EGCG to the ferritin cage potentially reducing enzymolysis in GI fluid. In summary, this work demonstrates a novel nanocarrier for stabilization and sustained release of bioactive polyphenols.

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Section: Introductionmentioning

confidence: 99%

Epigallocatechin Gallate (EGCG) Decorating Soybean Seed Ferritin as a Rutin Nanocarrier with Prolonged Release Property in the Gastrointestinal Tract

Yang

Sun

Zhang

et al. 2016

Plant Foods Hum Nutr

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show abstract

“…and Kuo T.H., 2014), quercetin (Ha H.-K. et al, 2013) and (-)-epigallocatechin-3-gallate (Hu B. et al, 2012) into chitosan based nanoparticles. This is due to the fact that nanoparticles formulated from bare chitosan is unstable and can be easily dissociated at low pH which potentially leads to the release of the encapsulated biomolecules.…”

Section: Organic-organic Nanoparticle Conjugatesmentioning

confidence: 99%

“…Chitosan, a cationic polyaminosaccharide, have high-density amino groups and mucoadhesive properties, allowing facile chemical modification and complexation with negatively charged molecules (Sahdev P. et al, 2014). By exploiting the charge mediated ionic interactions, a wide variety of biomolecules such as proteins (Mattu C. et al, 2013), plasmid DNA and antigens as well as bioflavonoids (Ha H.-K. et al, 2013;Hosseini S.F. et al, 2013) have been successfully incorporated into chitosan nanoparticles.…”

Section: Types Of Biological Nanoparticlesmentioning

confidence: 99%

“…This is due to the fact that nanoparticles formulated from bare chitosan is unstable and can be easily dissociated at low pH which potentially leads to the release of the encapsulated biomolecules. By mixing the chitosan with other biological compounds such as fucoidan, β-lactoglobulin, and peptide, hybrid nanoparticles with remarkable improvement in stability, encapsulation efficiency and functional properties were obtained (Ha H.-K. et al, 2013;Hu B. et al, 2012;Huang Y.C. and Kuo T.H., 2014).…”

Section: Organic-organic Nanoparticle Conjugatesmentioning

confidence: 99%

“…In this regard, nanoparticles from biomolecules origin are the most suited for that purpose (Ha H.-K. et al, 2013). Chitosan and whey protein have been widely used as encapsulant of neutraceuticals, food ingredients, probiotics and enzymes due to their ease of availability in large quantity in combination with their good physical and mechanical properties.…”

Section: Foodsmentioning

confidence: 99%

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Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Saallah

Lenggoro

2018

KONA

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In the past few decades, enormous advances have been achieved in the field of particle technology and the trend has been shifted from macro to micro and recently to the nanoscale. Integration of nanotechnology and biotechnology has paved the way to the development of biological nanoparticles, derived from biomolecules, and biomolecule-nanoparticle conjugates for numerous applications. This review provides an overview of various types of biological nanoparticles and the methods of their fabrication with primary emphasis on the drying methods, particularly on the newly emerging technique, the electrospraying. Recent advances in the integration of biomolecules with nanoparticles in the past five years to present are also discussed. Finally, the application of the biomolecule-nanoparticle conjugates in various fields including medicals and pharmaceuticals, biosensors and bioelectronics, foods, and agricultures are also highlighted.

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Chitosan Applications for the Food Industry

Gutiérrez

2017

Chitosan

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Formation and characterization of quercetin-loaded chitosan oligosaccharide/β-lactoglobulin nanoparticle

Cited by 71 publications

References 38 publications

Epigallocatechin Gallate (EGCG) Decorating Soybean Seed Ferritin as a Rutin Nanocarrier with Prolonged Release Property in the Gastrointestinal Tract

Epigallocatechin Gallate (EGCG) Decorating Soybean Seed Ferritin as a Rutin Nanocarrier with Prolonged Release Property in the Gastrointestinal Tract

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Chitosan Applications for the Food Industry

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