Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds

Panagiotopoulou, Margarita; Papadaki, Sofia; Krokida, Magdalini

doi:10.1016/j.sajce.2022.01.004

Cited by 10 publications

(6 citation statements)

References 65 publications

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“…As shown in Table 1 , the PVP and Cu (II) concentrations were reduced from 20 to 6.6% ( w / v ) and from 3 to 0.2% ( w / v ), respectively, to reduce the viscosity and promote the particle formation by electrospraying process [ 38 , 39 ], as well as to avoid the formation of copper salt precipitates. Moreover, the sprayed A, sprayed B, and sprayed C solutions were electrosprayed with a higher shear rate of ca.…”

Section: Resultsmentioning

confidence: 99%

Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying

et al. 2022

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Electrospinning technology was used to produced polyvinylpyrrolidone (PVP)-copper salt composites with structural differences, and their virucidal activity against coronavirus was investigated. The solutions were prepared with 20, 13.3, 10, and 6.6% w/v PVP containing 3, 1.0, 0.6, and 0.2% w/v Cu (II), respectively. The rheological properties and electrical conductivity contributing to the formation of the morphologies of the composite materials were observed by scanning electron microscopy (SEM). SEM images revealed the formation of electrospun PVP-copper salt ultrafine composite fibers (0.80 ± 0.35 µm) and electrosprayed PVP-copper salt composite microparticles (1.50 ± 0.70 µm). Energy-dispersive X-ray spectroscopy (EDS) evidenced the incorporation of copper into the produced composite materials. IR spectra confirmed the chemical composition and showed an interaction of Cu (II) ions with oxygen in the PVP resonant ring. Virucidal composite fibers inactivated 99.999% of coronavirus within 5 min of contact time, with moderate cytotoxicity to L929 cells, whereas the virucidal composite microparticles presented with a virucidal efficiency of 99.999% within 1440 min of exposure, with low cytotoxicity to L929 cells (mouse fibroblast). This produced virucidal composite materials have the potential to be applied in respirators, personal protective equipment, self-cleaning surfaces, and to fabric coat personal protective equipment against SARS-CoV-2, viral outbreaks, or pandemics.

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Section: Resultsmentioning

confidence: 99%

Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying

et al. 2022

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“…The encapsulation of substances in microstructures or nanostructures is a technology used to encapsulate bioactive components in a matrix [242]. During encapsulation, microor nanospheres and micro-or nanofibers are formed.…”

Section: Encapsulation Of Bioactive Compoundsmentioning

confidence: 99%

“…By applying a high voltage (1 to 30 kV), the polymer droplet located at the tip of the needle is highly electrified and the inductive charges are uniformly distributed over its entire surface. Subsequently, due to the electrostatic field, the droplet transforms from a spherical shape into a conical formation, the so-called "Taylor cone" [242,260]. When the voltage exceeds a specified value for each substance, the electric force "supercharges" the surface tension of the drop and, depending on the intensity of the electric field, a jet of solution is ejected from the tip of the needle.…”

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confidence: 99%

Innovative Bioactive Products with Medicinal Value from Microalgae and Their Overall Process Optimization through the Implementation of Life Cycle Analysis—An Overview

Papadaki,

Tricha,

Panagiotopoulou

et al. 2024

Marine Drugs

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Microalgae are being recognized as valuable sources of bioactive chemicals with important medical properties, attracting interest from multiple industries, such as food, feed, cosmetics, and medicines. This review study explores the extensive research on identifying important bioactive chemicals from microalgae, and choosing the best strains for nutraceutical manufacturing. It explores the most recent developments in recovery and formulation strategies for creating stable, high-purity, and quality end products for various industrial uses. This paper stresses the significance of using Life Cycle Analysis (LCA) as a strategic tool with which to improve the entire process. By incorporating LCA into decision-making processes, researchers and industry stakeholders can assess the environmental impact, cost-effectiveness, and sustainability of raw materials of several approaches. This comprehensive strategy will allow for the choosing of the most effective techniques, which in turn will promote sustainable practices for developing microalgae-based products. This review offers a detailed analysis of the bioactive compounds, strain selection methods, advanced processing techniques, and the incorporation of LCA. It will serve as a valuable resource for researchers and industry experts interested in utilizing microalgae for producing bioactive products with medicinal properties.

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“…9 Conversely, reducing the flow rate tends to result in smaller and more uniform nanoparticles. 87 Additionally, the flow rate can impact the encapsulation efficiency of active ingredients within the nanoparticles. Extremely high flow rates may lead to poor encapsulation efficiency, while an optimal flow rate can enhance encapsulation efficiency.…”

Section: Effect Of Process Parametersmentioning

confidence: 99%

Review on electrospray nanoparticles for drug delivery: Exploring applications

Patel,

Haemmerich

2024

Polymers for Advanced Techs

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Electrospraying has emerged as a versatile technique in the pharmaceutical field due to its potential in drug delivery and formulation. With its advantages of cost‐effectiveness, reproducibility, ease of operation, and scalability, electrospraying offers numerous benefits for pharmaceutical applications. Notably, the production of nanoparticles using electrospraying provides unique properties, including small size, drug encapsulation capabilities, biocompatibility, and scalability. Electrospray nanoparticles have demonstrated significant promise in various drug delivery routes, such as oral and topical administration. These nanoparticles enhance drug stability, protection, and permeability, effectively overcoming limitations associated with these routes. Moreover, electrospray nanoparticles have proven valuable in targeted drug delivery, improving drug bioavailability and efficacy. Their ability to penetrate tissues and cells enables enhanced drug delivery to specific sites within the body. Additionally, electrospray nanoparticles can be tailored with targeting ligands or responsive components for controlled release and combination therapy, exhibiting successful applications in cancer treatment and neurological disorders. Therefore, electrospray nanoparticle technology shows great promise in biomedical applications, offering a versatile platform for targeted drug delivery and therapeutic interventions. This comprehensive review examines the various drug delivery applications of electrospraying and provides insights into its possibilities and challenges. The paper discusses the principles, methods, and parameters of electrospraying, while also exploring its use in fabricating drug delivery systems, addressing poorly soluble drugs. By synthesizing the findings from multiple studies, this review offers a comprehensive understanding of electrospraying's current state and potential in the pharmaceutical industry.

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Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds

Cited by 10 publications

References 65 publications

Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying

Virucidal PVP-Copper Salt Composites against Coronavirus Produced by Electrospinning and Electrospraying

Innovative Bioactive Products with Medicinal Value from Microalgae and Their Overall Process Optimization through the Implementation of Life Cycle Analysis—An Overview

Review on electrospray nanoparticles for drug delivery: Exploring applications

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