Formation and Extractive Desulfurization Mechanisms of Aromatic Acid Based Deep Eutectic Solvents: An Experimental and Theoretical Study

Zhao, Xiuxiu; Zhu, Guoqiang; Jiao, Lingying; Fang, Yu; Xie, Congxia

doi:10.1002/chem.201801631

Cited by 66 publications

(29 citation statements)

References 30 publications

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“…Also, the viscosity of all of the [Car][Tau] ILs decreased with an increase in temperature (Figure 2b and Table S1). A similar trend was observed in the density results (Figure 2c,d 29,30 Excitingly, the Kamlet−Taft parameter of the ILs was also affected by temperature. It can be observed from Figure 2f that the polarization parameters π* and β decreased with an increase in temperature.…”

Section: ■ Experimental Sectionsupporting

confidence: 84%

“…For the [Car][Tau] ILs, another Kamlet–Taft solvation discoloration parameter, bipolar/polarizability (π*) was also obtained, showing a relatively high value (1.2). Considering that polar molecular solvents usually have high π* values, these [Car][Tau] ILs showed a greatly enhanced affinity for weakly polar bioactive compounds. , Excitingly, the Kamlet–Taft parameter of the ILs was also affected by temperature. It can be observed from Figure f that the polarization parameters π* and β decreased with an increase in temperature.…”

Section: Resultsmentioning

confidence: 99%

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Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity

Lü

et al. 2021

ACS Sustainable Chem. Eng.

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Tumor is one of the most serious forms of abnormal growth that endangers human health today; its morbidity and mortality are both increasing every year. Most of the antitumor drugs used currently cannot be absorbed well by the human body because of their poor solubility and low bioavailability. Therefore, the prevention and treatment of tumors are still of high significance. These challenges can be addressed by the use of ionic liquids (ILs). Half of the antitumor drugs currently in the market are salts linked together by ILs. Compared to the solid form of the drug, the salt that is liquid at room temperature or body temperature shows good solubility, absorption, and stability. Therefore, in this study, we combined taurine with antitumor activity and alkaloids with biological activity (L-(−)-carnitine or betaine) to produce IL salts possessing the merits of both these components to develop an efficient and cost-effective drug delivery system for tumor treatment. Taurine-based ILs can deliver proteins such as insulin or dextran, which are promising drug delivery carriers. In vitro experiments showed that the taurine-based IL exhibited good biocompatibility, non-toxicity, and antitumor activity. Compared to the blank group, the proliferation inhibition rate of human colon adenocarcinoma cells (Caco-2) treated with different concentrations of taurine-based ILs increased significantly. The inhibitory effect of the taurine-based IL on Caco-2 cell proliferation became more pronounced with an increase in its concentration and the treatment time. Moreover, the results suggested that the combination of taurine-based ILs and chemotherapy drugs can improve the efficacy of chemotherapy drugs and reduce their adverse reactions. Interestingly, taurine-based ILs can inhibit the growth of tumor cells by inducing apoptosis in tumor cells after 4 h. This demonstrates the immense potential of taurine-based ILs in inhibiting the growth of tumor cells.

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Section: ■ Experimental Sectionsupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity

Lü

et al. 2021

ACS Sustainable Chem. Eng.

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“…Figure 1 i, j and S11 reveal the electron density of LB system by ESP analysis. The mutual attraction between the negatively electronegativity region of BL around the oxygen atoms and the positively charged regions around Li + leads to the formation of a stable structure [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte

et al. 2022

Nano-Micro Lett.

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Highlights A novel amide-based nonflammable electrolyte is proposed. The formation mechanism and solvation chemistry are investigated by molecular dynamics simulations and density functional theory. An inorganic/organic-rich solid electrolyte interphase with an abundance of LiF, Li3N and Li–N–C is in situ formed, leading to spherical lithium deposition. The amide-based electrolyte can enable stable cycling performance at room temperature and 60 ℃. Abstract The formation of lithium dendrites and the safety hazards arising from flammable liquid electrolytes have seriously hindered the development of high-energy-density lithium metal batteries. Herein, an emerging amide-based electrolyte is proposed, containing LiTFSI and butyrolactam in different molar ratios. 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether and fluoroethylene carbonate are introduced into the amide-based electrolyte as counter solvent and additives. The well-designed amide-based electrolyte possesses nonflammability, high ionic conductivity, high thermal stability and electrochemical stability (> 4.7 V). Besides, an inorganic/organic-rich solid electrolyte interphase with an abundance of LiF, Li3N and Li–N–C is in situ formed, leading to spherical lithium deposition. The formation mechanism and solvation chemistry of amide-based electrolyte are further investigated by molecular dynamics simulations and density functional theory. When applied in Li metal batteries with LiFePO4 and LiMn2O4 cathode, the amide-based electrolyte can enable stable cycling performance at room temperature and 60 ℃. This study provides a new insight into the development of amide-based electrolytes for lithium metal batteries.

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“…The depression in the melting point is related to the interaction between the DES components that prevents the crystallization of the mixture (Meng et al 2016). The hydrogen bonding appears to be the main interaction mode between the DES components, whereas the influence of other interactions, such as the van der Waals forces, cannot be excluded (Zhao et al 2018). Although external solvents can be used to prepare DESs, they can be obtained readily in solventfree conditions by heating at a temperature that is lesser than the melting point of the individual components (Zhang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical and thermal succinylation of softwood sawdust in presence of deep eutectic solvent to produce lignin-containing wood nanofibers

et al. 2021

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In this study, the effect of the deep eutectic solvent (DES) based on triethylmethylammonium chloride and imidazole on the mechanochemical succinylation of sawdust was investigated. The sawdust was ball milled in the presence of succinic anhydride and the effects of different amounts of the DES on the carboxylic acid content and particle size were studied with and without post-heating. The carboxylic acid content significantly increased with the addition of the DES and by using 1.5 mass excess of the DES compared to sawdust; milled sawdust with 3.5 mmol/g of carboxylic acid groups was obtained using 60 min post-heating at 100 °C. The particle size was found to depend strongly on DES-to-wood ratio and a change in size-reduction characteristics was observed related to fiber saturation point. After mechanochemical milling, three succinylated sawdust samples with different carboxylic acid contents were disintegrated into wood nanofibers and self-standing films were produced. Although the mechanical properties of the films were lower than the cellulose nanofibers, they were higher or in line with oil- and biobased polymers such as polypropene and polylactic acid, respectively. Because of their amphiphilic nature, wood nanofibers were found to be effective stabilizers of water–oil emulsions.

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Formation and Extractive Desulfurization Mechanisms of Aromatic Acid Based Deep Eutectic Solvents: An Experimental and Theoretical Study

Cited by 66 publications

References 30 publications

Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity

Taurine-Based Ionic Liquids for Transdermal Protein Delivery and Enhanced Anticancer Activity

Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte

Mechanochemical and thermal succinylation of softwood sawdust in presence of deep eutectic solvent to produce lignin-containing wood nanofibers

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