Formation and pH-controlled assembly of amphiphilic gold nanoparticles

Simard, Joseph M.; Briggs, Cheryl; Boal, Andrew K.; Rotello, Vincent M.

doi:10.1039/b004162i

Cited by 145 publications

(124 citation statements)

References 15 publications

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“…Molecules, such as mercaptocarboxylic acids, that are used to stabilize nanoparticles in the aqueous phase are often readily soluble in organic solvents, e.g. toluene or tetrahydrofuran (Simard et al 2000). Thus, transfer from organic to the aqueous phase can occur spontaneously (Kanaras et al 2002;Algar & Krull 2007), while the transfer of nanoparticles from the aqueous to the organic phase is often more difficult because ligands for the organic phase are often very poorly soluble in the aqueous phase.…”

Section: (A) Ligand Exchangementioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,409

1,092

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Inorganic colloidal nanoparticles are very small, nanoscale objects with inorganic cores that are dispersed in a solvent. Depending on the material they consist of, nanoparticles can possess a number of different properties such as high electron density and strong optical absorption (e.g. metal particles, in particular Au), photoluminescence in the form of fluorescence (semiconductor quantum dots, e.g. CdSe or CdTe) or phosphorescence (doped oxide materials, e.g. Y 2 O 3 ), or magnetic moment (e.g. iron oxide or cobalt nanoparticles). Prerequisite for every possible application is the proper surface functionalization of such nanoparticles, which determines their interaction with the environment. These interactions ultimately affect the colloidal stability of the particles, and may yield to a controlled assembly or to the delivery of nanoparticles to a target, e.g. by appropriate functional molecules on the particle surface. This work aims to review different strategies of surface modification and functionalization of inorganic colloidal nanoparticles with a special focus on the material systems gold and semiconductor nanoparticles, such as CdSe/ZnS. However, the discussed strategies are often of general nature and apply in the same way to nanoparticles of other materials.

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Section: (A) Ligand Exchangementioning

confidence: 99%

Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles

Sperling

Parak

2010

Phil. Trans. R. Soc. A.

1,409

1,092

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“…A new type of particles capped with two different ligands at the same time were synthesized by the method proposed by Simard et al (2000). To 60 mg of Au-SC 8 NPs we added 317.1 mg of 11-thioundecanoic acid (Aldrich 98%) diluted in 2 ml of tetrahydrofuran.…”

Section: Sample Preparationmentioning

confidence: 99%

“…Simard et al (2000) developed a synthesis method that we have used to produce gold NPs simultaneously capped with both octanethiol and thiolated undecanoic acid molecules (sample labelled Au-SC 8 /SC 11 COOH). Finally, following the synthesis method presented by Templeton et al (1999), we have synthesized water soluble gold NPs capped with tiopronin (Au-ST), which is a synthetic thiol-containing biomolecule.…”

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confidence: 99%

Electronic structure, magnetic properties, and microstructural analysis of thiol-functionalized Au nanoparticles: role of chemical and structural parameters in the ferromagnetic behaviour

et al. 2008

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Gold nanoparticles (NPs) have been stabilized with a variety of thiol-containing molecules in order to change their chemical and physical properties; among the possible capping systems, alkane chains with different lengths, a carboxylic acid and a thiol-containing biomolecule (tiopronin) have been selected as protecting shells for the synthesized NPs; the NPs solubility in water or organic solvents is determined by the protecting molecule. A full microstructural characterization of these NPs is presented in the current research work. It has been shown that NPs capped with alkanethiol chains have a marked ferromagnetic behaviour which might be also dependent on the chain length. The simultaneous presence of Au-Au and Au-S bonds together with a reduced particle diameter, and the formation of an ordered monolayer protective shell, have been proved to be key parameters for the ferromagnetic-like behaviour exhibited by thiol-functionalized gold NPs.

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“…Charge, crystallinity, and chemical properties (such as hydrophilicity) of surfaces determine the stability, structure, and reactivity of nanoparticles. [1][2][3][4][5][6][7][8][9][10][11] In this respect, it is essential to have a capability to control and modify the surfaces of nanoparticles.…”

mentioning

confidence: 99%