Formation and Stabilization of Fluorescent Gold Nanoclusters Using Small Molecules

Bao, Yuping; Yeh, Hsin‐Chih; Zhong, Cheng; Ivanov, Sergei A.; Sharma, Jaswinder; Neidig, Michael L.; Vu, Dung M.; Shreve, Andrew P.; Dyer, R. Brian; Werner, James H.; Martinez, Jennifer S.

doi:10.1021/jp909580z

Cited by 89 publications

(68 citation statements)

References 40 publications

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“…Alternatively, top-down etching of preformed large nanoparticles down to desired NC sizes has received much attention due to many available synthetic strategies for the large nanoparticles. In this aspect, polyethylenimine [38], dihydrolipoic acid [39,40], thiols [41][42][43], Good's buffers [44], cyclodextrins [45], and even hydrochloric acid [46] have been employed as effective etchants. Recently, large nanoparticles have been reported to be even fluorescent after being sensitized by thiols [47,48].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of DNA-templated fluorescent gold nanoclusters

et al. 2012

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Water-soluble and red-emitting gold nanoclusters (Au NCs) were synthesized with single-stranded DNA as a promising biotemplate and dimethylamine borane as a mild reductant. The fluorescent Au NCs can be formed in a weakly acidic aqueous solution that is free from the simultaneous formation of large nanoparticles. The cluster feature of the formed Au species has been revealed by fluorescence spectra, absorption spectra, and transmission electron microscopy. Additionally, DNA sequences could be used to tune the Au NCs' emissions. The as-prepared Au NCs display high stability at physiological pH condition, and thus, wide potential applications are anticipated for the biocompatible fluorescent Au NCs serving as nanoprobes in bioimaging and related fields.

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Section: Introductionmentioning

confidence: 99%

Synthesis of DNA-templated fluorescent gold nanoclusters

et al. 2012

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“…Third, metal nanoclusters (NCs) made of different metals have attracted considerable attention in past few years because of their unique optical, electrical and chemical properties emerging as promising candidates in the fields of biosensors, molecular imaging and catalysis [46,47]. These metal NCs need to be stabilized and different molecules including dendrimers, small molecules DNA and proteins have been used for this purpose [48][49][50]. Repeat proteins can be used for the controlled stabilization and order arrangement of these NCs and expand their potential applications ( Figure 3C).…”

Section: Applications Of Protein Biomolecular Templatingmentioning

confidence: 99%

Biomolecular templating of functional hybrid nanostructures using repeat protein scaffolds

Romera

Couleaud

Mejías

et al. 2015

Biochemical Society Transactions

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The precise synthesis of materials and devices with tailored complex structures and properties is a requisite for the development of the next generation of products based on nanotechnology. Nowadays, the technology for the generation of this type of devices lacks the precision to determine their properties and is accomplished mostly by 'trial and error' experimental approaches. The use of bottom-up approaches that rely on highly specific biomolecular interactions of small and simple components is an attractive approach for the templating of nanoscale elements. In nature, protein assemblies define complex structures and functions. Engineering novel bio-inspired assemblies by exploiting the same rules and interactions that encode the natural diversity is an emerging field that opens the door to create nanostructures with numerous potential applications in synthetic biology and nanotechnology. Self-assembly of biological molecules into defined functional structures has a tremendous potential in nano-patterning and the design of novel materials and functional devices. Molecular self-assembly is a process by which complex 3D structures with specified functions are constructed from simple molecular building blocks. Here we discuss the basis of biomolecular templating, the great potential of repeat proteins as building blocks for biomolecular templating and nano-patterning. In particular, we focus on the designed consensus tetratricopeptide repeats (CTPRs), the control on the assembly of these proteins into higher order structures and their potential as building blocks in order to generate functional nanostructures and materials.

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“…; copyright 2009, American Chemical Society), and (b) schematic illustration of visual detection of Hg 2+ based on FRET between POSSFF and R‐AuNC (reproduced with permission from ref. ; copyright 2011, American Chemical Society); and fluorescence excitation (gray) and emission (black) spectra of HEPES (c) and MES (d) stabilized AuNCs (reproduced with permission from ref …”

Section: Fluorescent Probes Based On Aunps/ncsmentioning

confidence: 99%

Optical Reading of Contaminants in Aqueous Media Based on Gold Nanoparticles

Zhu

Peng

et al. 2014

Small

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With increasing trends of global population growth, urbanization, pollution over-exploitation, and climate change, the safe water supply has become a global issue and is threatening our society in terms of sustainable development. Therefore, there is a growing need for a water-monitoring platform with the capability of rapidness, specificity, low-cost, and robustness. This review summarizes the recent developments in the design and application of gold nanoparticles (AuNPs) based optical assays to detect contaminants in aqueous media with a high performance. First, a brief discussion on the correlation between the optical reading strategy and the optical properties of AuNPs is presented. Then, we summarize the principle behind AuNP-based optical assays to detect different contaminants, such as toxic metal ion, anion, and pesticides, according to different optical reading strategies: colorimetry, scattering, and fluorescence. Finally, the comparison of these assays and the outlook of AuNP-based optical detection are discussed.

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Formation and Stabilization of Fluorescent Gold Nanoclusters Using Small Molecules

Cited by 89 publications

References 40 publications

Synthesis of DNA-templated fluorescent gold nanoclusters

Synthesis of DNA-templated fluorescent gold nanoclusters

Biomolecular templating of functional hybrid nanostructures using repeat protein scaffolds

Optical Reading of Contaminants in Aqueous Media Based on Gold Nanoparticles

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