Formation and stabilization of ibuprofen nanoparticles by pulsed rapid expansion of supercritical solutions

Hermsdorf, Dana; Jauer, Stephan; Signorell, Ruth

doi:10.1080/00268970701222714

Cited by 25 publications

(26 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Methods such as expansion from supercritical solutions, [207] laser evaporation from a solid or a frozen solution help to study molecules of increasing complexity. [46,[208][209][210][211] Aggregates of oligofunctional chiral molecules involving hydrogen-bonded networks, up to and including peptide model dimers [212] are of special interest.…”

Section: Discussionmentioning

confidence: 99%

Chirality Recognition between Neutral Molecules in the Gas Phase

2008

View full text Add to dashboard Cite

Noncovalent interactions are particularly intriguing when they involve chiral molecules, because the interactions change in a subtle way upon replacing one of the partners by its mirror image. The resulting phenomena involving chirality recognition are relevant in the biosphere, in organic synthesis, and in polymer design. They may be classified according to the permanent or transient chirality of the interacting partners, leading to chirality discrimination, chirality induction, and chirality synchronization processes. For small molecules, high-level quantum chemical calculations for such processes are feasible. To provide reliable connections between theory and experiment, such phenomena are best studied in vacuum isolation at low temperature, using rotational, vibrational, electronic, and photoionization spectroscopy. We review these techniques and the results which have become available in recent years, with special emphasis on dimers of permanently chiral molecules and on the influence of conformational flexibility. Analogies between the microscopic mechanisms and macroscopic phenomena and between intra- and intermolecular cases are drawn.

show abstract

Section: Discussionmentioning

confidence: 99%

Chirality Recognition between Neutral Molecules in the Gas Phase

2008

View full text Add to dashboard Cite

show abstract

“…There is growing interest in the study of biologically relevant molecules in the gas phase. Methods such as expansion from supercritical solutions,207 laser evaporation from a solid or a frozen solution help to study molecules of increasing complexity 46. 208–211 Aggregates of oligofunctional chiral molecules involving hydrogen‐bonded networks, up to and including peptide model dimers212 are of special interest.…”

Section: Discussionmentioning

confidence: 99%

Nipple-sparing mastectomy

Rusby

Smith

Gui

2010

British Journal of Surgery

171

View full text Add to dashboard Cite

Background: Although effective local control is the primary goal of surgery for breast cancer, the longterm aesthetic outcome is also important. Nipple-sparing mastectomy aims to address this, but there is no consensus on its clinical application. Evidence relating to oncological safety, surgical technique and early data on aesthetic outcome was reviewed. Methods:The review was based on a PubMed search using the terms 'nipple-sparing' or 'subcutaneous mastectomy' and 'breast cancer'.Results: Large pathological studies report occult nipple involvement with cancer in 5·6-31 per cent, reflecting variation in inclusion criteria. Recent clinical series with careful patient selection report local recurrence in less than 5 per cent of patients. The incidence of cancer in the retained nipple after risk-reducing mastectomy is less than 1 per cent. Nipple necrosis rates range up to 8 and 16 per cent for total and partial necrosis respectively. Variations in outcome result from differences in extent of resection, placement of incisions and type of breast reconstruction.Conclusion: Nipple-sparing mastectomy is an acceptable technique for women undergoing risk-reducing mastectomy. In the therapeutic setting, it may be offered to patients with smaller tumours far from the nipple and favourable pathological features. Women should be counselled about nipple necrosis and the potential for local recurrence.

show abstract

“…19͒ and approaching those used to dissolve a sizable amount of cholesterol 20 as a preliminary stage in the generation of nanometric aggregates in a beam by supersonic expansion. 21 At these conditions, similarities with the gas-phase configuration can hardly be recognized partly because of high temperature and because of strong and rapidly fluctuating interactions with the solvent. In this last case, cholesterol molecules are still predominantly oriented along the radial direction, diverging from the center of mass of the cluster.…”

Section: Introductionmentioning

confidence: 99%

Structural motifs of cholesterol nanoparticles

Cromie

Ballone

2009

The Journal of Chemical Physics

View full text Add to dashboard Cite

The growth sequence of gas-phase cholesterol clusters ͑Ch N ͒ with up to N = 36 molecules has been investigated by atomistic simulation based on an empirical force field model. The results of long annealings from high temperature show that the geometric motifs characterizing the structure of pure cholesterol crystals already appear in nanometric aggregates. In all clusters molecules tend to align along a common direction. For cluster sizes above the smallest ones, dispersion interactions among the hydrocarbon body and tails of cholesterol cooperate with hydrogen bonding to give rise to a bilayer structure. Analysis of snapshots from the annealing shows that the condensation of hydrogen bonds into a connected network of rings and chains is an important step in the self-organization of cholesterol clusters. The effect of solvation on the equilibrium properties of medium-size aggregates is investigated by short molecular dynamics simulations for the N = 30 and N = 40 clusters in water at near ambient conditions and in supercritical carbon dioxide at T = 400 K.

show abstract

Formation and stabilization of ibuprofen nanoparticles by pulsed rapid expansion of supercritical solutions

Cited by 25 publications

References 29 publications

Chirality Recognition between Neutral Molecules in the Gas Phase

Chirality Recognition between Neutral Molecules in the Gas Phase

Nipple-sparing mastectomy

Structural motifs of cholesterol nanoparticles

Contact Info

Product

Resources

About