Formation of bicalutamide nanodispersion for dissolution rate enhancement

Li, Chan; Li, Caixia; Le, Yuan; Chen, Jianfeng

doi:10.1016/j.ijpharm.2010.11.015

Cited by 54 publications

(32 citation statements)

References 55 publications

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“…Therefore, Low temper-ature would decrease the diffusion and growth kinetics at the crystal boundary layer interface. As a result, smaller drug particles are obtained at low temperature [4], [6], [17], [18].…”

Section: Effect Of Temperaturementioning

confidence: 99%

Antisolvent Crystallization of Poorly Water Soluble Drugs

Lonare¹,

Patel²

2013

IJCEA

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Abstract-The enhancement in bioavailability of the drugs is one of the most important concerning aspects of the pharmaceutical industries. Preparation of nanoparticles or microparticles of these drugs is the newest formulation strategies. The size and morphology of a drug are affecting several essential pharmaceutical properties. In general, the drug delivery system needs narrow particle size distribution with regular particle shape, particularly, an engineered drug particles to meet biopharmaceutical and processing needs. An antisolvent crystallization technique is being used to prepare nanoparticles or microparticles for poorly water soluble drugs at research scale. This method has an ability to change the solid-state properties of pharmaceutical substances including the modification of crystal formation and particle size distributions. Therefore, various operating variables and their effect on the particle size of poorly water soluble drugs in an anti-solvent crystallization have been reviewed.

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Section: Effect Of Temperaturementioning

confidence: 99%

Antisolvent Crystallization of Poorly Water Soluble Drugs

Lonare¹,

Patel²

2013

IJCEA

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“…Another reference tube filled with 3 mm spherical glass beads was used as a reference. Liquid nitrogen was used to maintain the sample and reference tube at low temperature to yield an accurate determination of surface area …”

Section: Methodsmentioning

confidence: 99%

NanoClusters Surface Area Allows Nanoparticle Dissolution with Microparticle Properties

Kuehl

El-Gendy

Berkland

2014

Journal of Pharmaceutical Sciences

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Poorly water soluble drugs comprise the majority of new drug molecules. Nanoparticle agglomerates, called NanoClusters, can increase the dissolution rate of poorly soluble compounds by increasing particle surface area. Budesonide and danazol, two poorly soluble steroids, were studied as model compounds. NanoCluster suspensions were made using a Netzsch MiniCer media mill with samples collected between 5 and 15 hours and lyophilized. DSC and PXRD were used to evaluate the physicochemical properties of the powders and BET was used to determine surface area. SEM confirmed NanoClusters were between 1 and 5 μm. NanoCluster samples showed an increase in dissolution rate compared to the micronized stock and similar to a dried nanoparticle suspension. BET analysis determined an increase in surface area of 8 times for budesonide NanoClusters and 10 to 15 times for danazol NanoClusters compared to micronized stock. Melting temperatures decreased with increased mill time of NanoClusters by DSC. The increased surface area of NanoClusters provides a potential micron-sized alternative to nanoparticles to increase dissolution rate of poorly water soluble drugs.

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“…Infrared (IR) spectroscopy is used to investigate the interactions between the lipids, drug and modifier according to [21]. The IR spectra of the bulk materials, a mixture of bulk materials, and RESSLNs modified with and without PEG2000 are shown in Fig.…”

Section: Ir Characterization Of Res-peg-slnsmentioning

confidence: 99%