Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

Li, Wei; Luo, Tian; Yong-ming, Yang; Tan, Xiuniang; Liu, Lifei

doi:10.1021/la504796v

Cited by 53 publications

(22 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In most cases, they provide the integration of pH sensitive nanoparticles (i.e. chitosan, Pluronic, etc) into biostable nanofibers, assuring a fast drug release in the local site by their peculiar chemistry susceptive to microenvironmental stimuli . In perspective, this will offer the unique opportunity to release “on demand” a precise amount of drug by controlling particle dissolution directly into the implant site, with relevant therapeutic benefits on in vivo treatments.…”

Section: Towards An Integrated Approachmentioning

confidence: 99%

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Guarino

Altobelli

Cirillo

et al. 2015

Polymers for Advanced Techs

View full text Add to dashboard Cite

Electrohydrodynamics-i.e. electrospinning, electrospraying and atomization-are gaining a growing interest in drug delivery applications, because of a large number of advantages including improved therapeutic index, localized delivery/targeting and controlled drugs toxicity level. In the past, microstructured platforms fabricated by the assembly of electrospun fibers have demonstrated to exhibit interesting features as bioactive carriers including extended surface area and high molecular permeability because of fully interconnected pore architecture, thus making the opportunity to incorporate a wide range of actives/drugs for different use. In these systems, molecular release occurs via various molecular transport pathways namely diffusion, desorption and scaffold degradation which may be tuned through a careful control of fiber morphology and composition. However, several shortcomings still concern the possibility to incorporate bioactive species, not exposing molecules to fast and/or uncontrolled denaturation, thus preserving biochemical and biological fiber functionalities. In this context, additive electro spraying (AES)-i.e. integration of electrosprayed nanoparticles into electrospun fiber network-is emerging as interesting route to control "separately" release and functional properties of the scaffolds in order to support cell activities by independent cues, during the tissue formation. Here, we describe the current advances on the use of electrospraying and/or electrospinning until more innovative integrated AES approaches to design molecularly loaded platforms able to spatially and timely release active molecules for different use in tissue engineering and molecular targeting.

show abstract

Section: Towards An Integrated Approachmentioning

confidence: 99%

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Guarino

Altobelli

Cirillo

et al. 2015

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…An important advantage of this type of colloidal particles is the fact that they possess in their structure two different environments (hydrophobic or hydrophilic) that can be exploited in, for example, the incorporation of two different drugs, thus performing dual drug delivery. Li et al [33] investigated a dual drug delivery approach by using two types of drugs, 5-FU and paenolum. 5-Fluorouracil is a hydrophilic chemotherapeutic drug principally used in colon cancer treatment, and paenolum is a hydrophobic molecule used to prevent blood platelet clotting, thus having anti-inflammatory properties.…”

Section: Electrospun Nanofibers For Drug Delivery Applicationmentioning

confidence: 99%

“…( A ) Accumulation of the drug mixture into the vesicle and ( B ) incorporation into the NF by electrospinning and drug release. Reprinted with permission from reference [33]. Copyright American Chemical Society, 2015.…”

Section: Figurementioning

confidence: 99%

Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy

et al. 2019

View full text Add to dashboard Cite

Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.

show abstract

Section: Inhibitory Biological Processes For Cancer Treatmentmentioning

confidence: 99%

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Wang

Cui

2020

Advanced Therapeutics

View full text Add to dashboard Cite

Electrospinning is a versatile technique for generating ultrathin fibers, which is widely applied in various biomedical applications. The properties and structures of the fibers are specifically engineered to meet the needs of particular applications. The impact of nanofibrous scaffolds on biological processes is related to the promotion or inhibition of specific cell or bioactive substance functions. Here, a novel analysis of the diverse roles of electrospun nanofibrous scaffolds is provided and recent advances in exploiting their binary attributes for applications in biomedicine are summarized. This review initially introduces the development techniques for electrospinning, specifically the engineering of electrospun nanofibers. Then, scaffold applications for cell migration, adhesion, proliferation, and accelerating regeneration in cardiac, nerve, skeletal muscle, bone tissue, and wound healing are presented. Moreover, their inhibitory properties in cancer treatments, antibacterial applications, anti‐adhesion, anti‐scarring, and inhibition of thrombus formation are summarized. Eventually, the potential for future work using multifunctional, electrospun, nanofibrous scaffolds, in order to further inspire the development of scaffolds for biomedical treatments is summarized and discussed.

show abstract

Formation of Controllable Hydrophilic/Hydrophobic Drug Delivery Systems by Electrospinning of Vesicles

Cited by 53 publications

References 50 publications

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Additive electrospraying: a route to process electrospun scaffolds for controlled molecular release

Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Contact Info

Product

Resources

About