Formation of Dentin-like Particles in Dentin Defects above Exposed Pulp by Controlled Release of Fibroblast Growth Factor 2 from Gelatin Hydrogels

Dentin Phosphophoryn Promotes Cellular Migration of Human Dental Pulp Cells

“…Kaida et al (29) found that the number of cells expressing BMPs gradually increased in reparative dentin formation. Furthermore, the induction of pulp cell differentiation and calcification by BMP-7 overexpression (30) and induction of reparative dentin formation by the control of FGF2 release from a carrier have also been reported (31). It is also known that BMP and FGF2 strongly induce DSPP expression (11,32).…”

Bovine serum albumin release from novel chitosan-fluoro-aluminosilicate glass ionomer cement: Stability and cytotoxicity studies

“…Animal experiments have revealed that only a minute amount of growth factors, such as 2.5 ng of TGFb1 in the adsorbable collagen membrane 26 or 100 mg of FGF2 in the hydrogel micropheres, as a direct pulp capping, can activate mineralization in the exposed pulp of rat molars. 9 Hence, the released protein from this material may be sufficient for further modification in clinical applications.…”

“…Biomaterials that can sustain the release of protein such as growth promoting factors or bioactive molecules may have a number of applications, including tissue engineering and vital pulp therapy. 7,8 There have been some studies involving material that can control the release of growth j o u r n a l o f d e n t i s t r y 3 7 ( 2 0 0 9 ) 6 8 6 -6 9 0 factor; for example, fibroblast growth factor 2 (FGF2) from hydrogel 9 and poly lactic-co-glycolic acid (PLGA) microparticles containing transforming growth factor beta1 (TGF b1), as pulp capping to promote dentin-pulp complex regeneration. 10 Many studies have shown that the interpolymer complex from the reaction of poly (acrylic acid) and chitosan can generate polyionic complexes, which can be used to prolong drug delivery.…”

Formation of Dentinal Bridge on Surface of Regenerated Dental Pulp in Dentin Defects by Controlled Release of Fibroblast Growth Factor–2 From Gelatin Hydrogels

“…Recently, we implanted free FGF-2 or gelatin hydrogels incorporating FGF-2 into dentin defects above an amputated pulp and found that a noncontrolled release of free FGF-2 only accelerated reparative dentin formation in the residual dental pulp, whereas a controlled release of FGF-2 from gelatin hydrogels induced formation of dentin-like particles in the pulp proliferating in the dentin defect above the amputated pulp, suggesting the possibility of a novel therapeutic approach for the dentin-pulp complex (29). However, the porous aggregate composed of dentin-like particles induced in the dentin defects was a less than ideal regenerated dentin structure.…”