Formation of gold decorated porphyrin nanoparticles and evaluation of their photothermal and photodynamic activity

Chen, Ruey-Juen; Chen, Pochung; Prasannan, Adhimoorthy; Vinayagam, Jayaraman; Huang, Chun-Chiang; Chou, Peng-Yi; Weng, Cheng-Chih; Tsai, Hsieh‐Chih; Lin, Shih‐Yin

doi:10.1016/j.msec.2016.03.034

Cited by 27 publications

(10 citation statements)

References 24 publications

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“…The phototoxicity of these dyes conjugates exhibits higher efficiency under light condition suggesting increase the PDT ability of these dyes when conjugated with nanoparticles due to generation of singlet oxygen and other ROS species from both naphthol dyes and nanoparticles. [46] That was confirmed previously that AuNPs have increased the UV-visible absorption with other dyes and is suggested in this study as well. [27,47] Evaluation of nanoparticles impact on the PSA of these dyes indicates the superiority of naphthol/AgNPs conjugates over naphthol/AuNPs conjugates.…”

Section: Photodynamic Activity Against Human Promyelocytic Leukemia Csupporting

confidence: 92%

Synthesis and In Vitro Evaluation of Anti‐Leukemic Potency of Some Novel Azo‐Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

et al. 2020

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Synthesis of some new mono azo organic compounds, based on 1‐arylazo‐2‐naphthol nucleus is performed by diazo‐coupling strategy of β‐naphthol with different 1ry aromatic amines. Interestingly, the monoazo products undergo functionalized reactions to obtain the target azo naphthol derivatives (3–14). The synthesized dyes are conjugated with gold and/ or silver nanoparticles by electrostatic interaction. Photodynamic therapeutic efficiencies of the synthesized naphthol azo dyes and their conjugates have been evaluated against promyelocytic leukemia cell lines (HL‐60) in dark and light conditions. Dye‐Nanometal conjugates act as photosensitizers (PSs) exhibiting an enhancement of the optical properties as well as in photodynamic therapeutic efficiencies in variable degrees depending on dye structure.

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Section: Photodynamic Activity Against Human Promyelocytic Leukemia Csupporting

confidence: 92%

Synthesis and In Vitro Evaluation of Anti‐Leukemic Potency of Some Novel Azo‐Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

et al. 2020

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“…This goal may be achieved in different ways, for instance by enhancing the delivery of PS to microorganisms (encapsulating the PS in nanoparticles) [137] or by increasing the 1 O 2 yield of the PS (by covalently binding the PS to the surface of the nanoparticles [138], or simply by mixing the nanoparticles and PS together). In some cases the nanoparticles themselves (for instance TiO2, fullerenes or quantum dots) have been shown to act as PS themselves and are capable of photodynamically inactivating the microorganisms [139].…”

Section: Biofilm Resistance To Apdimentioning

confidence: 99%

Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?

Kashef

Hamblin

2017

Drug Resistance Updates

256

173

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Infections have been a major cause of disease throughout the history of humans on earth. With the introduction of antibiotics, it was thought that infections had been conquered. However, bacteria have been able to develop resistance to antibiotics at an exponentially increasing rate. The growing threat from multi-drug resistant organisms calls for intensive action to prevent the emergence of totally resistant and untreatable infections. Novel, non-invasive, non-antibiotic strategies are needed that act more efficiently and faster than current antibiotics. One promising alternative is antimicrobial photodynamic inactivation (APDI), an approach that produces reactive oxygen species when dyes and light are combined. So far, it has been questionable if bacteria can develop resistance against APDI. This review paper gives an overview of recent studies concerning the susceptibility of bacteria towards oxidative stress, and suggests possible mechanisms of the development of APDI-resistance that should at least be addressed. Some ways to potentiate APDI and also to overcome future resistance are suggested.

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“…For example gold nanoparticles (AuNPs) are used as drug‐delivery platforms (Chen et al . 2016) and also as surface plasmon‐enhanced agents (Chu et al . 2016; Kashef et al .…”

Section: Discussionmentioning

confidence: 99%

Bacterial phototoxicity of biomimetic CdTe‐GSH quantum dots

Oetiker

Muñoz-Villagrán

Vásquez

et al. 2020

J. Appl. Microbiol.

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Aim Fluorescent semiconductor nanoparticles or quantum dots (QDs) have excellent properties as photosensitizers in photodynamic therapy. This is mainly a consequence of their nanometric size and the generation of light‐activated redox species. In previous works, we have reported the low‐cost biomimetic synthesis of glutathione (GSH) capped QDs (CdTe‐GSH QDs) with high biocompatibility. However, no studies have been performed to determine their phototoxic effect. The aim of this work was to characterize the light‐induced toxicity of green (QDs500) and red (QDs600) QDs in Escherichia coli, and to study the molecular mechanism involved. Methods and Results Photodegradation and reduction power of biomimetic QDs was determined to analyse their potential for radical generation. Escherichia coli cells were exposed to photoactivated QDs and viability was evaluated at different times. High toxicity was determined in E. coli cells exposed to photoactivated QDs, particularly QDs500. The molecular mechanism involved in QDs phototoxicity was studied by determining Cd2+‐release and intracellular reactive oxygen species (ROS). Cells exposed to photoactivated QDs500 presented high levels of ROS. Cells exposed to photoactivated QDs500 presented high levels of ROS. Finally, to understand this phenomenon and the importance of oxidative and cadmium‐stress in QDs‐mediated phototoxicity, experiments were performed in E. coli mutants in ROS and Cd2+ response genes. As expected, E. coli mutants in ROS response genes were more sensitive than the wt strain to photoactivated QDs, with a higher effect in green‐QDs500. No increase in phototoxicity was observed in cadmium‐related mutants. Conclusion Obtained results indicate that light exposure increases the toxicity of biomimetic QDs on E. coli cells. The mechanism of bacterial phototoxicity of biomimetic CdTe‐GSH QDs is mostly associated with ROS generation. Significance and Impact of the Study The results presented establish biomimetic CdTe‐GSH QDs as a promising cost‐effective alternative against microbial infections, particularly QDs500.

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Formation of gold decorated porphyrin nanoparticles and evaluation of their photothermal and photodynamic activity

Cited by 27 publications

References 24 publications

Synthesis and In Vitro Evaluation of Anti‐Leukemic Potency of Some Novel Azo‐Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

Synthesis and In Vitro Evaluation of Anti‐Leukemic Potency of Some Novel Azo‐Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?

Bacterial phototoxicity of biomimetic CdTe‐GSH quantum dots

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