This study investigates the mechanical properties and microstructural characteristics of explosion-welded Al/Cu two-layer strips during the ECAR process using finite element simulations and experiments. Furthermore, the explosion-welded Al/Cu two-layer strip was examined with various configurations to determine the effects of die angle and friction coefficient on the distributions of effective strain and stress. In addition, the experimental and computational approaches were utilized to explore the ECAR process in two routes, RA and RC, for three directions. Finite element simulations were run and validated using experimental data. The findings show that the ECAR method is effective to enhance the mechanical characteristics of the strips. Moreover, the obtained results represent that the ECAR process reduced the size of the grains. Furthermore, it was shown that by increasing the number of routes in the ECAR process, the stress values were increased. However, the ductility of the two-layer strip was decreased. According to the current study, the route and the number of routes used in the ECAR process have a considerable effect on the strength of the two-layer strip.