Formation of mucous membrane lesions secondary to prolonged use of one per cent aqueous gentian violet

Slotkowski, Eugene L.

doi:10.1016/s0022-3476(57)80098-5

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…Although gentian violet (GV) is widely used for skin and/or mucosal disinfection, in some circumstances, GV might lead to the unwanted side effects [4, 5]. Nyst et al [6] reported that side effects of GV were local irritation and ulceration which were infrequent and reversible.…”

Section: Discussionmentioning

confidence: 99%

Oral Adverse Reactions Caused by Over-the-Counter Oral Agents

Boras

Brailo

Rogulj

et al. 2015

Case Reports in Dentistry

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Over-the-counter products rarely cause unwanted reactions in the oral cavity. Oral reactions to these agents are not specific and might present with various clinical oral findings. Detailed medical history is a key to the proper diagnosis of these lesions and fortunately other diagnostic procedures are rarely needed. Lesions are usually managed with elimination of the offending agent and with topical steroids. In more severe cases systemic steroids should be applied.

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Section: Discussionmentioning

confidence: 99%

Oral Adverse Reactions Caused by Over-the-Counter Oral Agents

Boras

Brailo

Rogulj

et al. 2015

Case Reports in Dentistry

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“…3 Fifteen infants who developed oral lesions associated with gentian violet solutions administered for oral thrush have been reported. [3][4][5][6][7][8][9][10] Gentian violet solutions were of 0.5% to 2% strength and were applied usually 2 3,4,7 but up to 12 9 times a day. White-gray plaques usually occurred within the first 3 to 7 days, 5,7-9 involved the buccal mucosa and the floor of the mouth, and resolved within a week after cessation of gentian violet application.…”

Section: Discussionmentioning

confidence: 99%

The Worst Thrush I Have Ever Seen

Douvoyiannis

Swank²

2016

Pediatr Emer Care

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“…In addition, it has been used to determine the patency of the fallopian tube and to demonstrate VVF [1]. However, since Slotkowski reported the case of a patient developing ulceration of oral mucosa as a result of treatment, crystal violet has been recognized as a potential irritant [5]. Crystal violet should therefore be diluted with water to a 0.5% concentration before intravesical instillation or contact with any other mucosal surface [1].…”

Section: Discussionmentioning

confidence: 99%

Chemical cystitis due to crystal violet dye: a case report

et al. 2013

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IntroductionCrystal violet was commonly used for the treatment of oral and vaginal candidiasis or for sterilization during operations up to the 1960s. Because crystal violet is potentially toxic to mucosal membranes, it has been replaced with other disinfectants, and crystal violet is rarely used. We report a case of chemical cystitis due to intravesical instillation of crystal violet dye.Case presentationCrystal violet dye was instilled into the bladder of a 47-year-old Japanese woman to confirm the presence of a vesicovaginal fistula. Our patient developed symptoms of gross hematuria, frequent urination and lower abdominal pain. Computed tomography showed thickening of her whole bladder wall with spotted high-density lesions. Cystoscopy demonstrated desquamated epithelial cells and a hemorrhagic bladder wall. We treated our patient conservatively with nonsteroidal anti-inflammatory drugs and glucocorticoids. During follow-up, magnetic resonance images showed that the detrusor muscle of her bladder was normal. Our patient’s symptoms gradually improved and she completely recovered within six months.ConclusionConsidering the severe side effect of crystal violet, it would be better not to use this dye to examine conditions such as a vesicovaginal fistula. Magnetic resonance imaging may help to evaluate the level of damage in the bladder wall of patients with chemical cystitis.

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Formation of mucous membrane lesions secondary to prolonged use of one per cent aqueous gentian violet

Cited by 14 publications

References 6 publications

Oral Adverse Reactions Caused by Over-the-Counter Oral Agents

Oral Adverse Reactions Caused by Over-the-Counter Oral Agents

The Worst Thrush I Have Ever Seen

Chemical cystitis due to crystal violet dye: a case report

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