Formation of nanoparticles in aqueous solution from poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone)

Nguyen, Thi Hong Anh; Nguyễn, Văn Minh

doi:10.1088/2043-6254/1/2/025012

Cited by 11 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These peaks are absent in the FTIR spectrum from the empty PEG–PLA nanoparticles. The absorption band at 1180 cm −1 , 1748 cm −1 and 2930 cm −1 may be attributed to C–O stretching, C–O stretching, and C–H stretching in PEG–PLA, respectively 34. These peaks appear in both the quercetin loaded PEG–PLA nanoparticles and the empty PEG–PLA nanoparticles (Figure 2b).…”

Section: Resultsmentioning

confidence: 94%

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Wang

Bao

Ahire

et al. 2012

Adv Healthcare Materials

View full text Add to dashboard Cite

Polymer nanoparticles have emerged as a promising new strategy for the efficient delivery of drugs. They have several advantages when used as drug carriers, such as high stability, high capacity, improvement of drug bioavailability, as well as allowing for sustained drug release. Quercetin has therapeutic potential as an anticancer drug, but has poor solubility and low bioavailability. In this study it is shown that co-encapsulation of quercetin and fluorescent Silicon quantum dots (SiQDs) in poly (ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles can be used for simultaneous in vitro imaging and to improve the biocompatibility of quercetin. Fluorescent imaging with SiQDs can provide a new concept to monitor the delivery of anti-cancer drugs. The nanoparticles are synthesized based on the double emulsion method and are extensively characterized and assayed for cytotoxicity in vitro. HepG2 cells are incubated with quercetin and SiQDs dual-loaded PEG-PLA nanoparticles, resulting in a red fluorescent staining which can be detected with a confocal microscope. PEG-PLA nanoparticle encapsulated quercetin suppresses human hepatoma HepG2 cell proliferation more effectively than the free-standing form. In addition, nanoparticle-encapsulated quercetin significantly inhibits hydrogen peroxide-induced DNA damage in HepG2 cells. These data show that nanocapsulated quercetin possesses the potential bioactivity to reduce the drug dosage frequency, as well as increase patient compliance. The combination of polymeric nanoparticles and semiconductor quantum dots can allow monitoring of delivery, improve aqueous solubility, and enhance biocompatibility. Such nanoparticulated systems could shape the future of drug delivery.

show abstract

Section: Resultsmentioning

confidence: 94%

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Wang

Bao

Ahire

et al. 2012

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…An FTIR spectrum of synthesized PCEC triblock copolymer is shown in Figure 1. The absorption band at 1725 is related to stretching vibration of carbonyl group which confirms formation of copolymer (Ryu et al, 2001;Nguyen, 2010). Aliphatic CH stretching band of polyethylene oxide (PEO) and caprolactone were appeared at 2854 and 2923 cm-1 respectively.…”

Section: Synthesis and Characterization Results Of Pcecmentioning

confidence: 76%

Synthesis, Characterization and in vitro Anti-Tumoral Evaluation of Erlotinib-PCEC Nanoparticles

Barghi¹,

Asgari²,

Barar³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Development of a nanosized polymeric delivery system for erlotinib was the main objective of this research. Materials and Methods: Poly caprolactone-polyethylene glycol-polycaprolactone (PCEC) copolymers with different compositions were synthesized via ring opening polymerization. Formation of triblock copolymers was confirmed by HNMR as well as FT-IR. Erlotinib loaded nanoparticles were prepared by means of synthesized copolymers with solvent displacement method. Results: Physicochemical properties of obtained polymeric nanoparticles were dependent on composition of used copolymers. Size of particles was decreased with decreasing the PCL/PEG molar ratio in used copolymers. Encapsulation efficiency of prepared formulations was declined by decreasing their particle size. Drug release behavior from the prepared nanoparticles exhibited a sustained pattern without a burst release. From the release profiles, it can be found that erlotinib release rate from polymeric nanoparticles is decreased by increase of CL/PEG molar ratio of prepared block copolymers. Based on MTT assay results, cell growth inhibition of erlotinib has a dose and time dependent pattern. After 72 hours of exposure, the 50% inhibitory concentration (IC50) of erlotinib hydrochloride was appeared to be 14.8 μM. Conclusions: From the obtained results, it can be concluded that the prepared PCEC nanoparticles in this study might have the potential to be considered as delivery system for erlotinib.

show abstract

“…According to ISO-10993-5 [ 85 ], the RCV (%) values plotted in Figure 6 could be considered to be non-toxic. Additionally, growth of cells kept in contact with non-cytotoxic blank (drug-unloaded) NPs has been described to be not hindered, even at high concentrations [ 129 , 130 , 131 ]; as a result, proliferation can continue under in-vitro conditions. On the other hand, experimental results from the ex-vivo hemocompatibility assays of γ -Fe 2 O 3 and ( γ -Fe 2 O 3 /PLGA)/CS particles demonstrated a negligible effect on haemolysis, platelet activation, complement system activation, and plasma clotting time was observed ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

2021

View full text Add to dashboard Cite

A (core/shell)/shell nanostructure (production performance ≈ 50%, mean diameter ≈ 330 nm) was built using maghemite, PLGA, and chitosan. An extensive characterization proved the complete inclusion of the maghemite nuclei into the PLGA matrix (by nanoprecipitation solvent evaporation) and the disposition of the chitosan shell onto the nanocomposite (by coacervation). Short-term stability and the adequate magnetism of the nanocomposites were demonstrated by size and electrokinetic determinations, and by defining the first magnetization curve and the responsiveness of the colloid to a permanent magnet, respectively. Safety of the nanoparticles was postulated when considering the results from blood compatibility studies, and toxicity assays against human colonic CCD-18 fibroblasts and colon carcinoma T-84 cells. Cisplatin incorporation to the PLGA matrix generated appropriate loading values (≈15%), and a dual pH- and heat (hyperthermia)-responsive drug release behaviour (≈4.7-fold faster release at pH 5.0 and 45 °C compared to pH 7.4 and 37 °C). The half maximal inhibitory concentration of the cisplatin-loaded nanoparticles against human lung adenocarcinoma A-549 cells was ≈1.6-fold less than that of the free chemotherapeutic. Such a biocompatible and tri-stimuli responsive (maghemite/PLGA)/chitosan nanostructure may found a promising use for the effective treatment of lung cancer.

show abstract

Formation of nanoparticles in aqueous solution from poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone)

Cited by 11 publications

References 14 publications

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Synthesis, Characterization and in vitro Anti-Tumoral Evaluation of Erlotinib-PCEC Nanoparticles

A Tri-Stimuli Responsive (Maghemite/PLGA)/Chitosan Nanostructure with Promising Applications in Lung Cancer

Contact Info

Product

Resources

About