Formation of organically modified octacalcium phosphate in solutions containing various amounts of benzenedicarboxylic acids

Yokoi, Taishi; Kamitakahara, Masanobu; Kawashita, Masakazu; Ohtsuki, Chikara

doi:10.2109/jcersj2.121.219

Cited by 23 publications

(14 citation statements)

References 20 publications

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“…15,17 The Ca/P molar ratio of the CONTROL sample was slightly higher than that of Pure-OCP, namely 1.33. Additionally, a small amount of carbon was detected in the CONTROL sample (Table 1).…”

Section: Phase Purity Of Samplesmentioning

confidence: 93%

“…Calcite remained in the final products in the previous synthetic method when the amounts of dicarboxylic acids, such as Suc, Sub, phthalic acid and isophthalic acid, used to synthesize OCPCs were small. 15,17 The Ca/P molar ratio of the CONTROL sample was slightly higher than that of Pure-OCP, namely 1.33. Additionally, a small amount of carbon was detected in the CONTROL sample (Table 1).…”

Section: Phase Purity Of Samplesmentioning

confidence: 93%

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Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain

2015

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Octacalcium phosphate (OCP) is composed of apatitic and hydrated layers, and can incorporate dicarboxylate ions in its hydrated layers by substitution of HPO4(2-). The (100) interplanar spacing of OCP is increased by incorporation of dicarboxylate ions. Herein, we report continuous expansion of the interplanar spacing of OCP by incorporation of dicarboxylate ions with a side chain. We synthesized OCP with incorporated succinic acid (Suc) and mercaptosuccinic acid (Msuc) by a wet chemical process. The (100) interplanar spacing of OCP synthesized with Suc increased non-continuously as the amount of Suc used in the synthesis increased. In contrast, the (100) interplanar spacing of OCP synthesized with Msuc increased continuously with the amount of Msuc used during synthesis, and thus in the OCP. The values of the (100) interplanar spacing of OCP synthesized with Msuc first increased and then became constant as the amount of Msuc increased. OCP with incorporated Msuc formed a continuous solid solution. The expansion of the (100) interplanar spacing of OCP with incorporated Suc and Msuc depended on the chemical structure of the incorporated dicarboxylate ions. The only structural difference between Suc and Msuc is a mercapto (R-SH) side chain. Therefore, continuous solid solution formation was most likely induced by the R-SH side chain of Msuc. These results suggest that incorporation of dicarboxylic acids with a side chain is one approach to obtain OCP with arbitrary interlayer distance.

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Section: Phase Purity Of Samplesmentioning

confidence: 93%

Section: Phase Purity Of Samplesmentioning

confidence: 93%

Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain

2015

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“…7 shows the powder X-ray diffraction patterns of OCP synthesized in the presence of various concentrations of isophthalic acid. 56) Isophthalic acid was not incorporated when its concentration was lower than 10 mmol•dm ¹3 ; however, both OCP and OCP incorporated with isophthalate ions were formed at isophthalic acid concentrations of 20100 mmol•dm ¹3 . When the isophthalic acid concentration exceeded 250 mmol•dm ¹3 , only OCP incorporated with isophthalate ions was formed.…”

Section: Nanoscale: Incorporating Guest Molecules Into Ocpmentioning

confidence: 94%

“…Our research group focused on carboxy groups (COOH) and investigated the crystalline phases of calcium phosphate formed in poly(acrylamide-co-acrylic acid) hydrogels. 33) The calcium phosphate crystalline phase changed from OCP to HAp with increasing levels of acrylic acid in the copolymer hydrogel. On the other hand, the crystalline phase of calcium phosphate was observed to be independent of the concentration of free propionic acid present in the polyacrylamide reaction medium.…”

Section: Macroscale: Precipitating Calcium Phosphate Crystals In Polymentioning

confidence: 98%

The development of novel calcium phosphate–polymer composite biomaterials with macro- to nano-level controlled hierarchical structures

Yokoi

2019

J. Ceram. Soc. Japan

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The synthetic technique to control hierarchical structure is essential for the development of highly functional materials. In this article, we review the challenges involved in creating new calcium phosphatepolymer composites as artificial bone that extends beyond autologous bone, by combining hierarchical structural control at the macro, micro, and nano levels. Gel-mediated processing is a powerful method for preparing macroscopically homogeneous calcium phosphatepolymer composites, and the biomimetic approach is effective for controlling the microscopic morphologies of calcium phosphate particles formed in polymeric hydrogel matrices. Octacalcium phosphate (OCP), which is a member of the calcium phosphate family, has a layered structure. Controlling the nanoscopic structure of OCP through the incorporation of organic molecules into the interlayers of its crystal lattice is a promising approach for adding new functionalities and improving the biological properties of composite materials.

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“…In 1983, Monma 13 fortuitously discovered that hydrogen phosphate ions (HPO 4 2− ) in the hydrated layers of OCP could be substituted by an organic acid, namely succinic acid (HOOC (CH 2 ) 2 COOH), which is a type of saturated dicarboxylic acid. Further studies demonstrated the incorporation of a variety of dicarboxylate ions into OCP [14][15][16][17][18][19][20][21] . It has been reported that precisely controlling the layered structure of OCP at the molecular level would enable the application of dicarboxylate-ionincorporated OCP as a novel functional material for bone repair 22 and as a specific adsorbent for aldehydes 23 .…”

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confidence: 99%

Incorporation of tetracarboxylate ions into octacalcium phosphate for the development of next-generation biofriendly materials

et al. 2021

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Octacalcium phosphate (OCP; Ca8(HPO4)2(PO4)4 ∙ 5H2O) is a precursor of hydroxyapatite found in human bones and teeth, and is among the inorganic substances critical for hard tissue formation and regeneration in the human body. OCP has a layered structure and can incorporate carboxylate ions into its interlayers. However, studies involving the incorporation of tetracarboxylic and multivalent (pentavalent and above) carboxylic acids into OCP have not yet been reported. In this study, we investigate the incorporation of pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid), a type of tetracarboxylic acid, into OCP. We established that pyromellitate ions could be incorporated into OCP by a wet chemical method using an acetate buffer solution containing pyromellitic acid. The derived OCP showed a brilliant blue emission under UV light owing to the incorporated pyromellitate ions. Incorporation of a carboxylic acid into OCP imparted new functions, which could enable the development of novel functional materials for biomedical applications.

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Formation of organically modified octacalcium phosphate in solutions containing various amounts of benzenedicarboxylic acids

Cited by 23 publications

References 20 publications

Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain

Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain

The development of novel calcium phosphate–polymer composite biomaterials with macro- to nano-level controlled hierarchical structures

Incorporation of tetracarboxylate ions into octacalcium phosphate for the development of next-generation biofriendly materials

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