Transition to an innovative model of postindustrial development inevitably reinforces the territorial imbalances in the economy. One of the reasons for the emergence of interregional disproportions in the Russian economy is structural dysfunctions of the state's economy as a whole. Lack of strategic goal setting; orientation of the state economic policy on solving current problems; support for the priority development of the oil and gas industries; the destruction of the interregional and inter-sectoral interaction systems that developed in the industrial era-all of these factors have led to the gradual separation of the subjects of the federation. As a result, there has appeared clear differentiation of regions into "donors", ensuring a stable replenishment of the federal budget and "recipients", requiring constant financial support from the central government to ensure the minimum acceptable standard of living of the population. To ensure balanced economic growth and overcome the disparity of socioeconomic development of individual regions of the country, it is necessary to develop fundamentally new methods and tools for strategic management in the real sector of the economy. In order to accomplish this task, in the near future, it is necessary to focus on the issues of developing a methodology for the operative diagnostics and monitoring of socioeconomic disproportions of spatial development.