-The importance of geo-ecological studies is confirmed by an insufficient readiness of methodological approaches and conceptual bases of research of geo-ecological factors of innovative development of industrial clusters at the market transformation stage of the Russian economy, the analysis of regularities, factors and mechanisms of state regulation of "external effects" of economic growth. Along with it, the impossibility of direct borrowing of ready forms and institutes of government regulation of geo-ecological factors of innovative development in industrial clusters used abroad increases the importance of carrying out similar researches in Russia. So, technological and economic potential of Kuzbass -the most agglomerated industrial cluster of Western Siberia, Russia -should be used for investment in researching of transition to green economy and environment-saving mining, metallurgy and organic chemistry. The most perspective way of initiating geo-ecological development of industrial clusters is its neo-industrialization. It means modernization of raw-material industries on the new technological bases.