Formation of Thermally Stable Derivatives of Chlordiazepoxide and Its Desmethyl Metabolite for GLC

Gelbke, H; Schlicht, H J

doi:10.1002/jps.2600670843

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On-column Acylation1

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1981

1984

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“…Acylation reactions do not always result in the formation of the expected derivatives and it is therefore hazardous to assume the nature of a certain acylation product. For example, on acylation of chlordiazepoxide, two acetyl groups are incorporated in the molecule, one through a rearrangement involving the -CH,-NO= moiety [96].…”

Section: On-column Acylationmentioning

confidence: 99%

Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids

Hulshoff¹,

Lingeman²

1984

Journal of Pharmaceutical and Biomedical Analysis

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Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.

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Section: On-column Acylationmentioning

confidence: 99%