Formoxazine, a New Pyrrolooxazine, and Two Amines from the Marine–Mudflat‐Derived Fungus <i>Paecilomyces formosus</i>

Yun, Keumja; Leutou, Alain Simplice; Rho, Jung‐Rae; Son, Byeng Wha

doi:10.1002/bkcs.10615

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…Studies on the fungi isolated from mudflats and their bioactive secondary metabolites are also rare. To date, Chaetomium cristatum , Fusarium oxysporum , Aspergillus niger , Thielavia hyalocarpa , Thielavia sp., and Paecilomyces formosus have been reported and are known to produce cristazine (cytotoxic and antioxidant), oxysporizoline (antibacterial), 6,9-dibromoflavasperone (antioxidant), 1- O -(α- d -mannopyranosyl)geraniol (a biotransformation product of geraniol), thielaviazoline (antibacterial and antioxidant), and formoxazine (antibacterial and antioxidant), respectively [16,17,18,19,20,21]. The lack of studies is likely primarily due to the limited global distribution of mudflats and salterns.…”

Section: Introductionmentioning

confidence: 99%

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

et al. 2019

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Intertidal zones are unique environments that are known to be ecological hot spots. In this study, sediments were collected from mudflats and decommissioned salterns on three islands in the Yellow Sea of South Korea. The diversity analysis targeted both isolates and unculturable fungi via Illumina sequencing, and the natural recovery of the abandoned salterns was assessed. The phylogeny and bioactivities of the fungal isolates were investigated. The community analysis showed that the abandoned saltern in Yongyudo has not recovered to a mudflat, while the other salterns have almost recovered. The results suggested that a period of more than 35 years may be required to return abandoned salterns to mudflats via natural restoration. Gigasporales sp. and Umbelopsis sp. were selected as the indicators of mudflats. Among the 53 isolates, 18 appeared to be candidate novel species, and 28 exhibited bioactivity. Phoma sp., Cladosporium sphaerospermum, Penicillium sp. and Pseudeurotium bakeri, and Aspergillus urmiensis showed antioxidant, tyrosinase inhibition, antifungal, and quorum-sensing inhibition activities, respectively, which has not been reported previously. This study provides reliable fungal diversity information for mudflats and abandoned salterns and shows that they are highly valuable for bioprospecting not only for novel microorganisms but also for novel bioactive compounds.

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Section: Introductionmentioning

confidence: 99%

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

et al. 2019

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“…14-Hydroxycornexistin 75possessed high herbicidal activity against weeds and low phytotoxicity to corn, suggesting that other nonadrides may be of interest for evaluation as potential herbicides [54]. Compounds 130 and 132 displayed potent radical scavenging activity against DPPH with IC 50 values of 0.1 and 10 µM, respectively, which were 200 times higher than that of the positive control ascorbic acid (IC 50 of 20 µM) [70]. Butenolide 146 displayed potent DPPH radical scavenging activity with an IC 50 value of 11.6 µM, which was stronger than that of the positive control BHT (butylated hydroxytoluene) (with an IC 50 of 117.7 µM) [7].…”

Section: Neuritogenic Activitymentioning

confidence: 99%

“…Variotin (126) and three novel compounds, formosusins A-C (127-129), were isolated from cultures of the fungus P. formosus [69]. A large-scale culture of the marine mudflat-derived fungus P. formosus yielded a new pyrrolooxazine, formoxazine (130), a previously reported dipyrroloquinone derivative (131), and a 2-oxazolidinone analogue (132) [70]. Two maleimide-bearing compounds, including the new farinomalein (133), were identified from the fungus P. farinosus HF599 [70].…”

Section: Alkaloids and Other Nitrogen-containing Compoundsmentioning

confidence: 99%

“…A large-scale culture of the marine mudflat-derived fungus P. formosus yielded a new pyrrolooxazine, formoxazine (130), a previously reported dipyrroloquinone derivative (131), and a 2-oxazolidinone analogue (132) [70]. Two maleimide-bearing compounds, including the new farinomalein (133), were identified from the fungus P. farinosus HF599 [70]. A new tetramic acid derivative, paecilosetin (135), was characterized from the fungus P. farinosus isolated from infected insect larvae [71].…”

Section: Alkaloids and Other Nitrogen-containing Compoundsmentioning

confidence: 99%

“…Compound 125 moderately inhibited MRSA with an inhibition zone of 8 mm [61]. Compound 130 displayed antibacterial activity against MRSA and multidrugresistant S. aureus (MDRSA) with MICs of 6.25 µg/mL [70]. Farinomalein (133) significantly inhibited the plant pathogen Phytophthora sojae with an MIC value of 5 µg/disk, whereas the MIC of the antifungal agent amphotericin B was 10 µg/disk [80].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

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A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Liu

et al. 2020

Planta Med

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AbstractFungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attractive bioactivities has been reported from this genus. This review attempts to provide a comprehensive overview of Paecilomyces species, with emphasis on the chemical diversity and relevant biological activities of these metabolic products. Herein, a total of 148 compounds and 80 references are cited in this review, which is expected to be beneficial for the development of medicines and agrochemicals in the near future.

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Marine natural products

et al. 2018

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Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

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Formoxazine, a New Pyrrolooxazine, and Two Amines from the Marine–Mudflat‐Derived Fungus Paecilomyces formosus

Cited by 6 publications

References 7 publications

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Marine natural products

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