2020
DOI: 10.31788/rjc.2020.1315553
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FORMULA COMPARISON OF NANOEMULSION AND CREAM CONTAINING MICONAZOLE NITRATE: PENETRATION TEST USING FRANZ DIFFUSION CELLS AND ANTIFUNGAL ACTIVITY TEST ON Tricophyton mentagrophytes, Microsporum canis AND Candida albicans

Abstract: Miconazole nitrate is one of the antifungal agents applied to the skin. Miconazole nitrate has a low bioavailability if it implements for oral treatment due to poor solubility and has low absorption, therefore miconazole nitrate implemented as the antifungal agent for topically. In addition, the main problem of a drug is the treatment of topical for poor skin penetration ability. The aim of the current study was the comparison of the penetration and the antifungal activity of both dosages. Nanoemulsion and cre… Show more

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Cited by 2 publications
(4 citation statements)
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“…Nanoemulsions can dissolve lipophilic drugs resulting in the improvement of the penetration through the skin layer. Many studies have reported improved permeation from nanoemulsion formulations compared to microemulsions and liposomes [ 69 ].…”
Section: Resultsmentioning
confidence: 99%
“…Nanoemulsions can dissolve lipophilic drugs resulting in the improvement of the penetration through the skin layer. Many studies have reported improved permeation from nanoemulsion formulations compared to microemulsions and liposomes [ 69 ].…”
Section: Resultsmentioning
confidence: 99%
“…The viscosity of each formulations was determined at ambient temperature using Brookfield digital viscometer with spindle no.7 at 50 rpm (revolutions per minute), and the results was recorded. 10 In vitro skin permeation of miconazole nitrate gel The drug release kinetics studied using a modified Franz-type diffusion cell. Male rabbits weighing 1.8 kg were chosen for the in vitro studies.…”
Section: Viscosity Testmentioning
confidence: 99%
“…Miconazole nitrate nanoemulsion was applied to the surface of the skin in the donor compartment, The samples were withdrawn at different time intervals as much as 0.5 mL from the receptor compartment and analyzing of drug content using a UV-Visible spectrophotometer at a wavelength of 272 nm. 10…”
Section: Viscosity Testmentioning
confidence: 99%
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