Formula Optimization of Orally Disintegrating Tablet Containing Meloxicam Nanoparticles

Abstract

Meloxicam is one of the oxicam anti-inflammatory drugs that are effective to relieve toothaches, arthritis, dysmenorrhea, and fever. Meloxicam in this study was milled with High Energy Milling (HEM) method to obtain nano size and then direct compression method was used to produce Orally Disintegrating Tablet (ODT). ODT is designed to be rapidly dissolved on the tongue within a minute. It can be administered without water or chewing and may improve the bioavailability and effectiveness of the drug, and increase the patient's adherence. The present study aimed to understand the effects of Ac-Di-Sol and Kollidon CL as superdisintegrants, that were used separately or in combination, on the characteristics of nanoparticles meloxicam ODT. It was also to obtain the best proportion of combination between Ac-Di-Sol and Kollidon CL that can produce the optimum formula of meloxicam ODT. The effects of single or combined superdisintegrants were evaluated using Simplex Lattice Design (SLD). Ac-Di-Sol (X 1 ) and Kollidon CL (X 2 ) were independent variables, while dependent variables were friability (Y 1 ), disintegrating time (Y 2 ), wetting time (Y 3 ), and percent meloxicam release after 60 seconds (Y 4 ). Optimization of five nanoparticle meloxicam ODT formulas was conducted using Design Expert 7.1.5. The combination of Ac-Di-Sol 4.05mg (X 1 ) and Kollidon CL 10.95mg (X 2 ) in 150mg nanoparticles meloxicam ODT could produce optimal ODT characteristics. After verification, there was no difference between predicted value and observed value with p-value > 0.05.

In Vitro and in Vivo Evaluation of Ezetimibe Fast-Dissolving Films

“…On the film, the thickness was measured at 3 distinct places, and the average was calculated. Results were given in table 2 [18].…”

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“…Tablet hardness of all formulations fell in value between 4.6 to 5.0 kP that within range of acceptable value (Fatmawati et al, 2017). The friability of ketoconazole tablets were mostly below 1% and met specification required (Winarti et al, 2017), except for F1. It is quite possibly caused by the low amount of SDL and SSG that the former possesses plastic deformation behavior of amorphous phase to form compacted tablet and the last belongs to starch derivative with binder property (Rassu et al, 2006;Rowe et al, 2009).…”