FORMULASI DAN EFEK SALEP EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava,L.) DENGAN BASIS HIDROKARBON TERHADAP LUKA SAYAT PADA TIKUS JANTAN GALUR WISTAR

Abstract

ABSTRACT
 The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study
 aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon
 base formula and examine the effect of the ointment against cut wounds on wistar male rat. The
 EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with
 a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2
 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included
 organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity
 and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were
 analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by
 applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut
 wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney
 test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all
 ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH,
 viscosity and adhesion are significantly different, while the spredability is not significant.The
 EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound
 on the 9th day was reduced and compared to wound controlwas differentsignificantly.
 Keywords :Guava leaves, ointment, cut of wound.

PENGUJIAN AKTIVITAS ANALGETIK DAN ANTIPIRETIK EKSTRAK ETANOL DAUN TENDANI (Ganiothalamus macrophyllus (Blume) Hook. F. & Thomson)

“…Flavonoid selain berefek antiinflamasi, juga diduga dapat berefek sebagai analgetik dan antipiretik (Rustam and Arifin, 2020). Flavonoid dan alkaloid diduga dapat menghambat sintesis prostaglandin E-2 (suatu mediator demam perifer) melalui penghambatan sintesa prostaglandin, lebih tepatnya endoperoksida (Wulan et al, 2017). Berdasarkan hal tersebut peneliti melakukan uji aktivitas analgetik dan antipiretik daun tendani pada mencit.…”