Daun kersen (Muntingia calabura ) secara empiris di masyarakat digunakan untuk mengobati berbagai macam penyakit. Salah satu potensi yang dimiliki dari daun kersen adalah sebagai antioksidan. Senyawa aktif yang dimiliki oleh daun kersen yang memiliki aktivitas antioksidan diantaranya adalah fenolik, flavonoid, dan alkaloid. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan penetapan kadar flavonoid total ekstrak etil asetat daun kersen (Muntingia calabura). Pembuatan ekstrak etil asetat daun kersen menggunakan metode maserasi dengan pelarut etil asetat. Analisis aktivitas antioksidan menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil) dengan pembanding vitamin C. Penetapan kadar flavonoid total menggunakan metode spektrofotometri Ultra Ungu-Sinar Tampak dengan pembanding Quersetin. Hasil penapisan fitokimia menunjukkan adanya kandungan senyawa alkaloid, saponin, fenolik, flavonoid, dan tannin. Hasil pengujian aktivitas antioksidan ekstrak etil asetat daun kersen dengan nilai IC50 sebesar 53,25 µg/mL dengan penbanding vitamin C (IC50 25,74 µg/mL ). Hasil penetapan kadar flavonoid total sebesar 93,21 mgEQ/g Ekstrak. Kata kunci: antioksidan, flavonoid total, muntingia calabura

ABSTRAKDaun Kersen (Muntingia calabura L.) mengandung alkaloid, saponin, fenolik, flavonoid, dan tanin. Senyawa fenolik dan flavonoid memiliki aktivitas antioksidan. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan, penetapan kadar fenolik total dan flavonoid total ekstrak etanol daun kersen. Daun kersen dimaserasi menggunakan etanol 96% lalu diuapkan hingga diperoleh ekstrak etanol. Ekstrak etanol dilarutkan ke dalam air lalu dipartisi dengan n heksan dan etil asetat untuk memperoleh fraksi n heksan, fraksi etil asetat, dan fraksi air. Pengujian aktivitas antioksidan dari ekstrak dan fraksi-fraksi dilakukan dengan metode pengukuran penangkapan radikal bebas oleh 1,1difenil-2-pikrilhidrazil (DPPH) secara in vitro. Vitamin C digunakan sebagai kontrol positif dengan nilai IC 50 25,74 µg/mL. Kandungan fenolik total dan flavonoid total ditentukan dengan menggunakan metode kolorimetri menggunakan standar asam galat untuk fenolik total dan standar kuersetin untuk flavonoid total. Hasil penelitian menunjukkan bahwa fraksi etil asetat menunjukkan aktivitas antioksidan paling tinggi dengan nilai IC 50 79,37 µg/mL dibanding fraksi n heksan (101,36 µg/mL), ekstrak etanol (126,47 µg/mL ), dan fraksi air (129,85 µg/mL). Fraksi etil asetat mengandung kadar fenolik total paling tinggi yaitu sebesar 510,57 mg GAE/g ekstrak dibanding ekstrak etanol (311,10 mg GAE/g ekstrak), fraksi air (292,74 mg GAE/g ekstrak), dan fraksi n heksan (103,95 mg GAE/g ekstrak). Fraksi etil asetat mengandung kadar flavonoid total paling tinggi yaitu sebesar 76,32 mg QE/g ekstrak dibanding ekstrak etanol (39,63 mg QE/g ekstrak), fraksi air (14,29 mg QE/g ekstrak), dan fraksi n heksan 3,30 mg QE/g ekstrak). Kadar fenolik total dan flavonoid total berkorelasi positif terhadap aktivitas antioksidan. ABSTRACTMuntingia calabura L. leaves were contained alkaloids, saponins, phenolic, flavonoids, and tannin. Phenolic and flavonoids compound had antioxidant activity. The present study aims to determine the antioxidant activity, determination of total phenolic and flavonoid content of ethanol extract of Muntingia calabura L. leaves and its fractions. Muntingia calabura L. leaves were macerated with 96% ethanol and then evaporated until ethanol extract was obtained. The ethanol extract was dissolved into water and then partitioned with n hexane and ethyl acetate to obtain the n hexane fraction, ethyl acetate fraction and water fraction. Determination of antioxidant activity of extracts and fractions was performed by free radical capture measurement method by 1,1-diphenyl-2picrylhydrazyl (DPPH) in vitro. Vitamin C was used as a positive control with IC 50 value of 25.74 µg/mL. The total phenolic and flavonoid content were determined using the colorimetric method using standard gallic acid for total phenolics and standard quercetin for flavonoid content. The results showed that ethyl acetat fraction showed the highest antioxidant activity with IC 50 79.37 μg/mL value compared to n hexane fraction (101.36 μg/mL), ethanol extract (126.47 μg/mL), and ...

Ethanol extract of bitter melon leaves at a concentration of 5% has been shown to have mucolytic activity. For ease of use that is made of dosage forms syrup. Thickening agent serves to increase the viscosity and resist settling process resulting in a stable syrup. Gelatin has the ability to improve settling extract better than other thickening. This study aims to determine the effect of variations in the concentration of gelatin to the physical-chemical properties and activity of ethanol extract syrup mukolitik pare leaves the cow intestine mucus in vitro. Extraction of leaf bitter melon is done by percolation. EEDP was made into three syrup formulas using 1% (FII), 2% (FIII), 3% (FIV) gelatin thickener. There is also syrup without extract and gelatin (FI) as a control. The four syrup formulas were examined for physical chemical properties (organoleptic, homogeneity, pH, viscosity), and tested their mucolytic activity. Data on the results of activity tests in the form of viscosity were analyzed by Kruskal-Wallis followed by Mann-Whitney. Data from organoleptic examination, homogeneity, Ph were analyzed descriptively, while viscosity with Linear Regression. The results showed that EEDP syrup with a gelatin concentration of 1%; 2%; 3% have mucolytic activity. The results of examination of the physico-chemical properties of FII, III, and IV syrups have the same taste and color, sweet and bitter, and are greenish black in color, while FI syrup is sweet and yellowish in color. Homogeneous FI syrup, FIII and FIV syrup are evenly distributed, while FII syrup has coarse particles. Fourth pH normal syrup formula. Increased concentration of gelatin (1%; 2%; 3%) can increase the viscosity of syrupKeywords: ethanol extract of bitter melon leaves, syrup, gelatin

TOGA merupakan tanaman obat keluarga yang memiliki manfaat bagi kesehatan manusia, tanpa kecuali termasuk pengobatan diabetes melitus. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan ketrampilan warga masyarakat tentang pentingnya TOGA sebagai obat herbal untuk pencegahan dan pengobatan alternatif penyakit diabetes melitus. Kegiatan ini dilaksanakan di.RW XVI Kelurahan TambakAji. Bentuk kegiatannya yaitu penyuluhan dengan metode ceramah dan diskusi. Sasaran kegiatan adalah ibu-ibu PKK RW XVI, Kelurahan Tambak Aji. Langkah-langkah kegiatan meliputi persiapan, pelaksanaan, dan evaluasi. Setelah kegiatan pengabdian ini dilaksanakan, para ibu PKK RW XVI Kelurahan TambakAji telah mengetahui khasiat jenis-jenis TOGA dan cara pemanfaatannya untuk kesehatan, khususnya pengobatan diabetes melitus.Kata Kunci: TOGA, Diabetes Melitus, RW XVI, Kelurahan Tambak AjiPENDAHULUAN

ABSTRACT The ethanol extract of guava leaves (EEGL) is proven to heal various types of wounds.This study aims to determine the physicochemical characteristics of the EEGL ointment with a hydrocarbon base formula and examine the effect of the ointment against cut wounds on wistar male rat. The EEGL was obtained by maceration using 70% ethanol solvent. The ointment made 3 formulas with a ratio of hydrocarbon base composition (cera alba:vaselin album) namely F1 (2.5:92.5)%; F2 (5:90)%; F3 (7.5:87.5)%. The physicochemical characteristics of all ointments examined included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion. Organoleptic, homogeneity and pH data were analyzed descriptively, while viscosity, spreadability and adhesion data were analyzedstatistically. Testing the effect of all ointment formulas on the wound was done by applying 0.5 gram 2x a day for 9 days compared to wound control without treatment and positive control used commercial product.The parameter of effect measured was the length of the cut wound on the 9th day, then analyzed with the Kruskall Wallis test followed by the Mann Whitney test.The physicochemical characteristics of EEGL ointment (F1, F2, F3) are known that all ointment formulas are brown in color, typical of guava, homogeneous, pH according to skin pH, viscosity and adhesion are significantly different, while the spredability is not significant.The EEGL ointment had an effect on the cut wound of the male wistar rats, ie the length of the wound on the 9th day was reduced and compared to wound controlwas differentsignificantly. Keywords :Guava leaves, ointment, cut of wound.