FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN SALAM (Syzygium Polyanthum (Wight) Walpers.) DENGAN MENGGUNAKAN METODE DPPH (1,1-diphenyl-2-picrylhydrazyl)

Abstract

Bay leaf (Syzygium Polyanthum (Wight) Walpers.) is known contains flavonoids, saponins, tannins and vitamin C. Flavonoids and vitamin C have an antioxidant activity, since they have the ability to remove and effectively reduce a damaging oxidizer species. The aim of the study is to determine the impact of the bay leaf ethanol extract enhancement concentration towards an antioxidant activity of cream preparation by using the DPPH method. This research used laboratory experimental methods. Cream formulations are made with various concentrations 1%, 3%, 6% and 9%. The evaluation results of the bay leaf cream preparation has fulfilled the requirements of homogeneity, organoleptic, pH, adhesion, dispersion, and centrifugation. The results of the antioxidant activity test using the DPPH method using the UV-Vis spectrophotometer which was the most effective as an antioxidant cream from bay leaf extract was 3% with a value IC_50 = 1.4630 ppm and vitamin C as a comparison with a value IC_50 = 0.1131 ppm. From this research, it can be concluded that the cream formulation of bay leaf ethanol extract has fulfilled the physical test parameters, stabile, and had a powerful antioxidant activity.Keywords: : Bay Leaf (Sysigium Polyanthum (Wight) Walpers.), Antioxidant Cream, DPPH (1.1-Diphenyl-2-Picrylhydrazyl) Method ABSTRAKDaun salam (Syzygium Polyanthum (Wight) Walpers.) diketahui mengandung flavonoid, saponin, tanin dan vitamin C. Senyawa flavonoid dan vitamin C memiliki aktivitas sebagai antioksidan, karena memiliki kemampuan untuk menghilangkan dan secara efektif mengurangi spesies pengoksidasi yang merusak. Penilitian ini bertujuan untuk mengetahui pengaruh peningkatan kosentrasi ekstrak etanol daun salam terhadap aktivitas antioksidan pada sediaan krim dengan menggunakan metode DPPH. Penelitian ini mengggunakan metode eksperimental laboratorium. Formulasi sediaan krim dibuat dengan variasi konsentrasi 1%, 3%, 6% dan 9%. Hasil evaluasi sediaan krim daun salam memenuhi persyaratan homogenitas, organoleptis, pH , daya lekat, daya sebar, sentrifugasi. Hasil uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometer UV-Vis yang paling efektif sebagai krim antioksidan dari ekstrak daun salam adalah 3% memiliki nilai = 1,4630 ppm dan vitamin C sebagai pembanding memiliki nilai = 0,1131 ppm. Dari penilitian ini dapat disimpulkan bahwa sediaan krim ekstrak etanol daun salam memenuhi parameter uji fisik, stabil dan memiliki aktivitas antioksidan yang sangat kuat. Kata kunci : Daun Salam (Sysigium Polyanthum (Wight) Walpers.) Krim Antioksidan, Metode DPPH (1.1-Diphenyl-2-Picrylhydrazyl)

Formulation and Antioxidant Activity Analysis of Jotang Herb (Acmella paniculata) Extract Mask Cream

“…The greater the spreading power is, the better the physical properties of the cream preparation will be. 12 The results of the spreading power of the cream mask from the ethanol extract of jotang herb from the Table above showed an average value obtained for FO of 5.1 cm, for F1 of 5.4 cm, and F2 of 6.2 cm. These results indicated that the spreadability of the cream mask preparation met the standard requirements for a good spread, which is around 5-7 cm.…”

“…The cream is considered homogeneous when there is an even color equation and no particles are found in the cream. 12 The results obtained from the homogeneity test of the jotang herb extract cream mask from Formula 0, Formula 1, and Formula 2 showed a homogeneous composition. The active substance properties of the ethanol extract of the jotang herb were mixed with the M/A base so that phase collection and separation did not occur.…”

“…The resulting preparation should have an attractive color, a pleasant odor, and sufficient consistency to be comfortable to use. 12 The organoleptic test results obtained from the cream mask preparation of the ethanol extract of the jotang herb (Acmella paniculata) for Formula 0, Formula 1, and Formula 2 have the same form, namely semi-solid. The cream mask preparation Formula 0 (without extract) had a white color and was odorless, while Formula 1 with an extract concentration of 1 gram had a light green color and a distinctive jotang smell.…”

Telang Flower Extract (Clitoria Ternatea) as Antioxidant in Snack Sticks

“…Tubuh sangat membutuhkan senyawa antioksidan untuk melindunginya dari radikal bebas. Antioksidan dapat memperlambat atau menghambat kerusakan yang disebabkan oleh proses oksidasi (Apitalau, Edy and Mansauda, 2021). Bunga Telang, atau Clitoria ternatea, adalah salah satu tanaman dengan setiap bagian yang bermanfaat bagi tubuh manusia.…”

“…Rancangan yang digunakan dalam pelaksanaan kajian ini adalah metode Rancangan Acak Lengkap (RAL) dan dilakukan uji lanjutan mengunakan metode Duncan dan analisis data dengan SPSS serta uji aktivitas antioksidan menggunakan metode DPPH (Apitalau, Edy and Mansauda, 2021). Terdapat 5 perlakuan dan 3 ulangan.…”