FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)

Pratasik, Meyla C. M.; Yamlean, Paulina V. Y.; Wiyono, Weny

doi:10.35799/pha.8.2019.29289

Cited by 35 publications

(41 citation statements)

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“…Hasil perlakuan tersebut ekivalen dengan efek gravitasi selama satu tahun (Iskandar dkk., 2021). Pengujian ini dilakukan untuk mengetahui kestabilan krim setelah pengocokan dengan kecepatan tinggi dan ada atau tidaknya pemisahan pada sediaan krim (Pratasik, Yamlean and Wiyono, 2019). Hasil pengujian stabilitas mekanik sediaan krim minyak cendana yaitu tidak terjadi pemisahan fase minyak dan fase air pada sediaan krim (Tabel 3).…”

Section: Hasil Dan Pembahasanunclassified

Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Suena

Ariani

Antari

2022

JINTO

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Inflammation is the body's defense response used to fight agents that cause cell damage in an organism. One source of natural ingredients whose content can be developed as an anti-inflammatory with low side effects is Sandalwood (Santalum album L.). The pharmaceutical preparation chosen for the development of Sandalwood oil as an anti-inflammatory is a cream, because of its several advantages, namely, it is more convenient, practical, easy to use, not sticky, and easy to wash with water so it is easy to clean. The purpose of this study was to determine the physical quality of sandalwood oil cream using two variant concentrations of surfactant sodium lauryl sulfate 1.5% (F1) and 2.5% (F2) as an emulsifying agent, as well as to determine consumer perceptions of sandalwood oil cream. In ensuring pharmaceutical quality, the preparations made must meet several physical parameters including organoleptic tests, homogeneity tests, pH tests, mechanical stability tests, dispersibility tests, and hedonic tests. To find out whether there is a significant difference between F1 and F2, statistical data processing of cream physical quality was performed using SPSS 20 with an unpaired T-test if the data were normally distributed, and if the data were not normally distributed, the Mann-Whitney test was performed. The results of the research that has been carried out show that overall the two cream formulas have good physical quality and are quite liked by the panelists. From the results of the organoleptic test, homogeneity test, and pH test, it is known that F1 and F2 have no difference, and the results of the dispersion test and hedonic test show that there is no significant difference between F1 and F2.

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Section: Hasil Dan Pembahasanunclassified

Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Suena

Ariani

Antari

2022

JINTO

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“…Hasil uji Anova menunjukkan nilai signifikasi (p>0,05) menunjukkan nilai hasil uji pH tidak terdapat perbedaan bermakna dan dilanjutkan dengan uji Paired Sampel Test sebelum dan sesudah cycling test p>0,05 menunjukkan tidak ada perbedaan pada tiap kelompok. Pengujian viskositas bertujuan untuk mengetahui mudah atau tidaknya sediaan untuk diaplikasikan yang ditunjukkan pada saat pengadukan menurut [14] persyaratan viskositas yang baik pada sediaan semi solid adalah sebesar 4000-40.000 cPs [8]. Pengujian iritasi kulit bertujuan untuk melihat apakah sediaan krim yang dibuat dapat menimbulkan gejala iritasi atau tidak pada saat digunakan.…”

Section: Hasil Dan Pembahasanunclassified

Formulasi Sediaan Krim Anti-aging dari Ekstrak Kolagen Limbah Sisik Ikan Bandeng (Chanos chanos)

Wahid¹,

Karim²,

Sari³

2022

J. Sains. Kes.

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Penuaan dini merupakan kerusakan yang terjadi pada kulit akibat radikal bebas yang terbentuk melalui proses metabolisme dan dampak negatif lingkungan. Sisik ikan bandeng dipercaya mengandung kolagen yang dapat menghambat proses penuaan dini pada kulit. Penelitian ini bertujuan untuk mengetahui apakah formulasi krim anti-aging dari kolagen limbah sisik ikan bandeng (Chanos chanos) dapat memenuhi syarat mutu stabilitas sediaan dan untuk mengetahui konsentrasi efektif pada krim anti-aging. Sisik ikan bandeng diekstraksi dengan metode maserasi dan dikeringkan kemudian diformulasikan dalam bentuk sediaan krim dengan konsentrasi 5%, 6% dan 7% dan dilanjutkan dengan evaluasi sediaan meliputi uji organoleptik, homogenitas, pH, daya sebar, viskositas, uji iritasi dan uji aktivitas yang dilakukan kepada 16 orang sukarelawan dengan pengujian pada kulit punggung tangan selama empat minggu. Hasil penelitian krim anti-aging dari hasil uji stabilitas krim anti-aging ekstrak kolagen sisik ikan bandeng (Chanos chanos) dengan konsentrasi 5%, 6% dan 7% sudah memenuhi syarat mutu stabilitas sediaan krim dan dari hasil uji aktivitas kadar air (moist) dan kadar minyak sediaan krim anti-aging dengan konsentrasi 5%, 6% dan 7% sudah memberikan efek anti-aging dalam memperbaiki kondisi kulit dengan nilai signifikansi pada tiap konsentrasi diperoleh nilai (P>0,05) menunjukkan tidak ada perbedaan bermakna pada tiap konsentrasi. Dapat di simpulkan bahwa krim anti-aging konsentrasi 5% sudah memberikan efek anti-aging dalam memperbaiki kondisi kulit punggung tangan.

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“…Sampel kulit ini digunakan untuk pembuatan preparat HE agar dapat mengetahui letak, persebaran, dan luas kolagen pada luka. [12]…”

Section: Perlakuan Hewan Cobaunclassified

Uji Efektivitas Krim Bunga Kamboja (Plumeria Sp.) Dalam Penyembuhan Ulkus Kaki Diabetikus

Suhartanto¹,

Yusuf²,

Prijadi³

2022

ESSENTIAL

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Introduction: Diabetes mellitus is a disease with a high number of cases. Complication of diabetes mellitus, such as diabetic foot ulcer, is rarely discussed. Treatment of diabetic foot ulcers often become a burden due to high cost, so a breakthrough is needed. Flavonoids have been reported to have benefits on wound healing. One of the plants that contain flavonoids is frangipani flower (Plumeria sp.). Methods: The cream made in 3 concentrations : 25%, 50%, and 75%. Cream was given to 24 rats that had been induced with alloxan. The cream will be given 2 times a day and the wound area is observed for 7 days. The rats will be euthanized and histological observations are made by hematoxylin preparations for collagen that will be analysis by ImageJ. Results: Wound closure and collagen area of the treated group better than the control group. The average wound closure of group I was 37.25%, group II was 75.75%, group III was 66.67%, and group IV was 61.70%. The average area of collagen in group I is 265776 pixels2, group II is 399579.5 pixels2, group III is 281749.75 pixels2, and group IV is 271382.9 pixels2. Discussion: The best result is group II. Increasing the dose of the cream didn’t give more significant effect so 25% dose was the maximum effective dose (MaxED). Conclusion: The administration of frangipani flower extract cream (Plumeria sp.) effective for diabetic foot ulcers and the maximum effective dose was 25%. Keywords: frangipani flower, diabetic foot ulcers, collagen, flavonoids

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FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)

Cited by 35 publications

References 0 publications

Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Formulasi Sediaan Krim Anti-aging dari Ekstrak Kolagen Limbah Sisik Ikan Bandeng (Chanos chanos)

Uji Efektivitas Krim Bunga Kamboja (Plumeria Sp.) Dalam Penyembuhan Ulkus Kaki Diabetikus

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