Formulasi Mouthwash Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr) dengan Variasi Konsentrasi Gliserin sebagai Antibakteri Terhadap Streptococcus mutans ATCC 25175

Maharani, Novita; Aisiyah, Siti; Purwaningsih, Desi

doi:10.37013/jf.v10i2.137

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Table 2 shows that the mouthwash preparation made from HAp-chitosan-bay leaf oil does not occur in separation and can be interpreted as a homogeneous formula. A good preparation will not experience phase separation because this will impact the long-term use of the preparation and reduce its efficacy [27].…”

Section: Fourier Transform Infra-red (Ftir)mentioning

confidence: 99%

Utilization of Hydroxyapatite-Chitosan-Bay Leaf Oil (Syzygium Polyanthum W.) as Antibacterial for Streptococcus Mutants

Adriani,

Cahyaningrum

2024

J. Pijar.MIPA

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Dental caries is a disease that can damage hard tooth tissue caused by the activity of Streptococcus mutans bacteria. Streptococcus mutans bacteria are the leading cause of dental caries disease. Efforts to prevent dental caries can be made using toothpaste, but toothpaste cannot reach areas that are difficult to reach with a toothbrush. Another method that can be used is mouthwash. This study was developed with the active ingredient compound HAp-chitosan-bay leaf oil in mouthwash to have an antimicrobial effect to prevent dental caries. This study aimed to determine the chemical physics characteristics and antibacterial activity of mouthwash preparations based on hydroxyapatite-chitosan-bay leaf oil. In this study, the active ingredients hydroxyapatite-chitosan-bay leaf oil was used with variations in the concentration of bay leaf oil, namely 0.5, 1.5, and 2.5 %. FT-IR characterization showed the presence of OH, N-H, CH, C=O, C=C, C-O, and PO43- functional groups. The pH test on the mouthwash showed compliance with the quality standard for mouthwash pH, which has a pH range of 5-7. The homogeneity test results in the mouthwash preparation showed no sediment or separation. Antibacterial activity testing showed that the HAp-chitosan-bay leaf oil mouthwash preparation inhibited the growth of Streptococcus mutans bacteria. The inhibition zone in the strong category with an average of 12.75 mm was shown in the HAp-chitosan-bay leaf oil mouthwash preparation formulation with a concentration of 2.5% bay leaf oil with the addition of sodium lauryl sulfate (SLS).

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Section: Fourier Transform Infra-red (Ftir)mentioning

confidence: 99%

Utilization of Hydroxyapatite-Chitosan-Bay Leaf Oil (Syzygium Polyanthum W.) as Antibacterial for Streptococcus Mutants

Adriani,

Cahyaningrum

2024

J. Pijar.MIPA

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“…The percent transmittance of the solution was measured at a wavelength of 650 nm using UV-Vis spectrophotometry. Deionized aqua was used as a blank during testing (Maharani et al, 2021). The particle size was determined using a particle size analyzer (PSA).…”

Section: Nanoemulsion Characterizationmentioning

confidence: 99%

Nanoemulsion-Based Mouthwash of Ethyl Acetate Fraction of Serai Wangi Stalk: Formulation, Characterization and Antibacterial Activity Test

Permatasari,

Veranita,

Soraya

et al. 2023

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Serai wangi or citronella (Cymbopogon nardus L.) has long been used in Indonesia as a component of traditional medicine. A recent study aimed to determine the antibacterial activity of the most active fraction of Citronella stalk extract and to formulate it into a nanoemulsion mouthwash. Fractionation of the ethanolic extract was carried out using liquid-liquid extraction, and it was found that the ethyl acetate fraction (EAF) was the most active. This fraction was then varied at concentrations of 25%, 12.5%, 6.25%, 3.125%, 1.5625%, and 0.78125% for the antibacterial activity test using the disc diffusion test method. To determine the potency of microbial activity, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated. Subsequently, the ethyl acetate fraction was formulated into a nanoemulsion and characterized by measuring the transmittance percentage, droplet size, and polydispersity index (pdI) using a particle size analyzer. The results showed that the ethyl acetate fraction at a concentration of 25% obtained an inhibition zone diameter of 10.67 mm. MIC and MBC values ??were obtained at a fraction concentration of 6.25%. In addition, characterization of formulae exhibited particle size and pdI as follow 101.6 nm and 0.681 (Formula I); 84.1 nm and 0.609 (Formula II); 108.3 nm and 0.527 (Formula III). Keywords: Citronella stalk; fractionation; Streptococcus mutans; nano-emulsion; mouth wash

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Determination of Physical Stability Spray Sunscreen of Extract Wungu Leaf (Graptophyllum pictum (L.) Griff) with Varied Concentrations of Glycerine as A Humectant

Rahmayanti,

Tri Maulidina,

Buana Putra

2023

RJPT

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Sunscreen is a preparation intended to counteract, reduce the effects, and protect the skin from ultraviolet (UV) radiation. Wungu leaf is one of the plants that contain antioxidants that can be used as a natural sunscreen preparation. In the manufacture of sunscreen, spray wungu leaf extract required additional materials in the form of humectants. Glycerin was chosen as a humectant with varying concentrations of 5%, 10%, and 15% in the formulation of a spray sunscreen which aims to improve the quality and maintain the stability of the resulting preparation. This study aims to determine the physical stability of the spray sunscreen preparation of wungu (Graptophyllum pictum (L.) Griff) leaf extract with varying concentrations of glycerin as a humectant. Spray sunscreen of wungu leaf extract was made in three formulas with variations in the concentration of glycerin used. The formulations that have been formulated are tested for physical stability by using the cycling test method for six cycles, and testing includes organoleptic, homogeneity, pH, viscosity, and diameter of the spray pattern. The organoleptic, homogeneity and pH tests of the preparations showed no significant changes after the physical stability test was carried out for six cycles with a significance pH value of 0.079 (<0.05). The resulting value still met the pH value criteria for topical preparations. The results of the viscosity test and spraying pattern showed an increase in the viscosity value and a decrease in the diameter of the spray pattern with a significant change with a significance of 0.01(<0.05) and 0.008 (<0.05). However, this change still met the physical criteria for topical preparations. Based on the study's results, it can be concluded that the spray sunscreen preparation of wungu leaf extract (Graptophyllum pictum (L.) Griff) with variations in glycerin concentration has good physical stability.

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Formulasi Mouthwash Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr) dengan Variasi Konsentrasi Gliserin sebagai Antibakteri Terhadap Streptococcus mutans ATCC 25175

Cited by 4 publications

References 3 publications

Utilization of Hydroxyapatite-Chitosan-Bay Leaf Oil (Syzygium Polyanthum W.) as Antibacterial for Streptococcus Mutants

Utilization of Hydroxyapatite-Chitosan-Bay Leaf Oil (Syzygium Polyanthum W.) as Antibacterial for Streptococcus Mutants

Nanoemulsion-Based Mouthwash of Ethyl Acetate Fraction of Serai Wangi Stalk: Formulation, Characterization and Antibacterial Activity Test

Determination of Physical Stability Spray Sunscreen of Extract Wungu Leaf (Graptophyllum pictum (L.) Griff) with Varied Concentrations of Glycerine as A Humectant

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