Formulasi Sediaan Patch Transdermal dari Rimpang Rumput Teki (Cyperus Rotundus L.) untuk Pengobatan Nyeri Sendi  Pada Tikus Putih Jantan

Rahim, Farida; Deviarny, Chris; Yenti, Revi; Ramadani, Putri

doi:10.36434/scientia.v6i1.34

Cited by 6 publications

(8 citation statements)

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“…Ringan atau beratnya sediaan plester hidrogel tentunya dipengaruhi oleh bobot sediaan dan tergantung pula dari ketebalan plester hidrogel. Ketebalan sediaan plester hidrogel dikatakan baik apabila ketebalannya kurang dari 1 mm [11]. Hasil uji ketebalan terdapat pada tabel 4.…”

Section: Uji Ketebalan Plester Hidrogelunclassified

Formulasi dan Uji Aktivitas Sediaan Plester Hidrogel Ekstak Etanol Daun Randu (Ceiba pentandra (L.) Gaertn) sebagai Antipiretik

Purwasih,

Endah,

Nofriyaldi

2023

J. Sains Kes.

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Antipyretics are drugs that work by suppressing body temperature in a state of fever. Randu leaf (Ceiba pentandra (L.) Gaertn) is one of the plants that has activity as an antipyretic and can be formulated in the form of fever-reducing hydrogel patch transdermal preparations. This study aims to determine the physical properties of hydrogel patch drug of ethanol extract of randu leaves and to determine the antipyretic activity of hydrogel plaster preparations of ethanol extract of randu leaves against male white rat test animals (Rattus norvegicus) induced with 5% peptone. The method used is experimental method. The extract was formulated into a hydrogel plaster preparation with a dose variation of 150 mg (FI), 300 mg (FII), and 600 mg (FIII). Evaluation tests were carried out on preparations such as organoleptic, pH, weight uniformity, folding resistance, preparation thickness, and moisture absorption. The results showed that the ethanol extract of randu leaf can be formulated into a hydrogel plaster dosage form that meets the physical evaluation requirements. The antipyretic activity test of randu leaf ethanol extract has a percent (%) of antipyretic activity in FI (150 mg) of 1.91%, in FII (300 mg) of 2.93% and FIII (600 mg) with a percent (%) of 3.25%. This study can be concluded that the preparation of hydrogel plaster ethanol extract of randu leaves has met the requirements of a good evaluation and has the best antipyretic activity in formula III (600mg) with a percent (%) antipyretic activity of 3.25%. Keywords: Antipyretic, Randu leaf, Fever, Hydrogel patch, Transdermal drug Abstrak Antipiretik merupakan obat yang bekerja dengan cara menekan suhu tubuh pada keadaan demam. Daun randu (Ceiba pentandra (L.) Gaertn) ialah salah satu tanaman yang memiliki aktivitas sebagai antipiretik dan berpotensi diformulasikan dalam bentuk sediaan transdermal plester hidrogel penurun demam. Penelitian ini bertujuan untuk mengetahui sifat fisik sediaan plester hidrogel ekstrak etanol daun randu dan mengetahui aktivitas antipiretik sediaan plester hidrogel ekstrak etanol daun randu terhadap hewan uji tikus putih jantan (Rattus norvegicus) yang diinduksi dengan pepton 5%. Metode yang digunakan yaitu metode eksperimental. Ekstrak diformulasikan menjadi sediaan plester hidrogel dengan variasi dosis 150 mg (FI), 300 mg (FII), dan 600 mg (FIII). Dilakukan pengujian evaluasi sediaan seperti organoleptik, pH, keseragaman bobot, ketahanan lipat, ketebalan sediaan, dan daya serap kelembaban. Hasil penelitian menunjukan ekstrak etanol daun randu dapat diformulasikan dalam bentuk sediaan plester hidrogel yang memenuhi persyaratan fisik evaluasi. Uji aktivitas antipiretik ekstrak etanol daun randu memiliki persen (%) aktivitas antipiretik pada FI (150 mg) sebesar 1,91%, pada FII (300 mg) sebesar 2,93% dan FIII (600 mg) dengan persen (%) sebesar 3,25%. Penelitian ini dapat disimpulkan bahwa sediaan plester hidrogel ekstrak etanol daun randu telah memenuhi persyaratan evaluasi yang baik dan memiliki aktivitas antipiretik terbaik pada formula III (600mg) dengan persen (%) aktivitas antipiretik 3,25%. Kata Kunci: Antipiretik, Daun randu, Demam, Plester hidrogel, Sediaan transdermal

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Section: Uji Ketebalan Plester Hidrogelunclassified

Formulasi dan Uji Aktivitas Sediaan Plester Hidrogel Ekstak Etanol Daun Randu (Ceiba pentandra (L.) Gaertn) sebagai Antipiretik

Purwasih,

Endah,

Nofriyaldi

2023

J. Sains Kes.

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“…Transdermal merupakan sistem penghantaran dengan menggunakan perekat yang mengandung senyawa obat, diletakkan melalui permukaan kulit untuk melepaskan zat aktif dalam dosis tertentu menuju aliran darah (1). Sistem ini adalah inovasi terbaru untuk mengurangi masalah bioavailabilitas obat pada jalur oral, sehingga dalam pemberian obat melalui kulit dapat mengalami peningkatan efek terapeutik yang baik (2).…”

Section: Pendahuluanunclassified

Pengaruh Kombinasi Polimer PVP:EC dan HPMC:EC Terhadap Sediaan Transdermal Pada Karakteristik Patch yang Baik : Review

Fuziyanti

Najihudin²,

Hindun³

2022

PJI

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Transdermal is a drug delivery system that is placed through the surface of the skin to release the active substance in a certain dose into the bloodstream. The main constituent component in the transdermal drug delivery system which has an effect on characteristics is polymer. One of the developments in the transdermal route is the manufacture of patch preparations. Physically, a good patch must be flexible, thin, smooth, homogeneous, have drying shrinkage and low moisture absorption. So the aim of this review article was to determine the effect of polymer combinations on transdermal preparations on good patch characteristics. The method used in this review article is a literature review of various journals published online, with the category of national and international journals. The results obtained 2 primary journals related to polymer combinations to transdermal preparations, namely the combination of PVP: EC and HPMC: EC. The results of the review show that the polymer combination can have an influence on the characteristics of the patch, including the fold resistance test, weight uniformity test, thickness test, drying shrinkage test and moisture absorption test.

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“…A transdermal insulin patch is an adhesive device containing drug molecules. This device can be affixed to the skin surface to distribute the correct drug dose in the systemic channel every specific period [39]. Transdermal treatment with this type of patch must be thin, smooth, flexible, and homogeneous [40] so that the drug particles delivered through the stratum corneum are able to diffuse well through lipid molecules [41].…”

Section: Figure 4 Insulin and Receptors [30]mentioning

confidence: 99%

Potential Use of Insulin Patch Technology as Transdermal Drug Delivery in Efforts to Treat Diabetes Mellitus

et al. 2022

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Diabetes Mellitus (DM) in Indonesia continues to increase from 2013 to 2018. Diabetes Mellitus is associated with the production of the hormone insulin in the cells of the pancreas. An increase in blood sugar levels can stimulate insulin secretion. There are several ways to treat Diabetes Mellitus, namely by using drugs, herbal methods, and insulin injections. In addition, one of the DM treatments that can reduce pain is using insulin patch technology as a transdermal treatment. The manuscript for this publication was made to find out the potential of using insulin patch technology as transdermal drug delivery to treat DM. Using a literature review research method that discusses four focus studies, including 1) the structure of the pancreas gland, 2) the mechanism of insulin hormone production by the pancreas gland, 3) the causes, symptoms, and conditions of patients with DM, and 4) insulin patch technology as a transdermal drug in the treatment of diabetes. DM treatment efforts. In the Langerhans section of the pancreas, some cells function to produce the hormone insulin. The amino acids that make up insulin are encoded by exons formed in insulin cells. Some causes of DM namely genetics, age, the influence of food, lack of physical activity, and an unhealthy lifestyle. Some of the symptoms, namely polyuria, polydipsia, polyphagia, etc. Patients with DM need insulin intake to help balance blood sugar levels, one of which is by using an insulin patch in which there is a microneedle containing insulin n-vinylpyrrolidone (NVP) and the enzyme glucose oxidase. After a literature review, it can be concluded that the insulin patch has excellent potential and promise because during the study tested on rats and pigs obtained good results and was able to lower blood sugar levels, although development is still needed. The manuscript of this publication still has shortcomings, so the author suggested to the next author to be able to multiply the latest sources related to insulin patch. Through the creation of the publication, the manuscript realized that diabetes mellitus is a form of human negligence in maintaining the body that God has designed carefully and regularly.

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Formulasi Sediaan Patch Transdermal dari Rimpang Rumput Teki (Cyperus Rotundus L.) untuk Pengobatan Nyeri Sendi Pada Tikus Putih Jantan

Cited by 6 publications

References 0 publications

Formulasi dan Uji Aktivitas Sediaan Plester Hidrogel Ekstak Etanol Daun Randu (Ceiba pentandra (L.) Gaertn) sebagai Antipiretik

Formulasi dan Uji Aktivitas Sediaan Plester Hidrogel Ekstak Etanol Daun Randu (Ceiba pentandra (L.) Gaertn) sebagai Antipiretik

Pengaruh Kombinasi Polimer PVP:EC dan HPMC:EC Terhadap Sediaan Transdermal Pada Karakteristik Patch yang Baik : Review

Potential Use of Insulin Patch Technology as Transdermal Drug Delivery in Efforts to Treat Diabetes Mellitus

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