Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS

Relationships Between the Properties of Self-Emulsifying Pellets and of the Emulsions Used as Massing Liquids for Their Preparation

“…2b that for inert emulsions it is negative due to the free fatty acids present in the oil which confirms previously reported data for self-emulsifying systems with nonionic surfactants (13,27). In the case of inert emulsions with RH60, the zeta potential is less negative compared to the other surfactants probably due to their generally greater droplet diameter and its influence on droplet mobility (Fig.…”

The Effect of Composition and Gastric Conditions on the Self-Emulsification Process of Ibuprofen-Loaded Self-Emulsifying Drug Delivery Systems: A Microscopic and Dynamic Gastric Model Study

“…The initial selection of the excipient mixture is usually based on the relative ability of the mixture to self-emulsify or self-micro-emulsify, the droplet size of the resulting emulsion or microemulsion, and the solubility of the drug within the vehicles. It should be noted that very few studies have investigated the effect of addition of the drug on the emulsification properties of these systems (7)(8)(9). Similarly, studies on the relationship between (micro-) emulsion droplet dimensions and enhancement of the drug bioavailability have produced ambiguous results.…”

Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential

“…The SEDDS formulation normally forms a clear dispersion instantaneously in the GI tract that remains stable on dilution (Spernath & Aserin, 2006). Such dispersions are referred to as either micro-or nanoemulsions, depending upon the globule size of the SEDDS formulation (Thi et al, 2009). The SEDDS formulations, which result in the formation of nano-sized globules, are termed self-nanoemulsifying drug delivery systems (SNEDDS).…”