Formulation and characterization of curcumin-loaded microemulsions: Evaluation of antioxidant stability and in vitro release

Amuti, Aibibai; Wang, Xue; Zan, Mingyang; Lv, Shaojun; Wang, Zhanzhong

doi:10.1016/j.molliq.2021.116881

Cited by 16 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, care should be taken to avoid light when releasing astaxanthin in vitro . Generally speaking, in the first 2 h, the highest release rate was in line with the design concept of rapid release of astaxanthin nanoparticles, thus laying a theoretical foundation for later investigation of the drug efficacy 56 . The astaxanthin is a poorly soluble drug.…”

Section: Resultsmentioning

confidence: 61%

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

et al. 2023

View full text Add to dashboard Cite

BACKGROUND Astaxanthin is a type of food‐derived active ingredient with antioxidant, antidiabetic and non‐toxicity functions, but its poor solubility and low bioavailability hinder further application in food industry. In the present study, through inclusion technologies, micellar solubilization and electrospray techniques, we prepared astaxanthin nanoparticles before optimizing the formulation to regulate the physical and chemical properties of micelles. We accomplished the preparation of astaxanthin nanoparticle delivery system based on single needle electrospray technology through use of 2‐hydroxypropyl‐β‐cyclodextrin and Soluplus® to improveme the release behavior of the nanocarrier. RESULTS Through this experiment, we successfully prepared astaxanthin nanoparticles with a particle size of approximately 80 nm, which was further verified with scanning electron microscopy and transmission electron microscopy. Furthermore, the encapsulation of astaxanthin molecules into the carrier nanoparticles was verified via the results of attenuated total reflectance intensity and X‐ray powder diffraction techniques. The in vitro release behavior of astaxanthin nanoparticles was different in media that contained 0.5% Tween 80 (pH 1.2, 4.5 and 6.8) buffer solution and distilled water. Also, we carried out a pharmacokinetic study of astaxanthin nanoparticles, in which it was observed that astaxanthin nanoparticle showed an effect of immediate release and significant improved bioavailability. CONCLUSION 2‐hydroxypropyl‐β‐cyclodextrin and Soluplus® were used in the present study as a hydrophilic nanocarrier that could provide a simple way of encapsulating natural function food with repsect to improving the solubility and bioavailability of poorly water‐soluble ingredients. © 2023 Society of Chemical Industry.

show abstract

Section: Resultsmentioning

confidence: 61%

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

et al. 2023

View full text Add to dashboard Cite

show abstract

“…As shown by Mostafa et al (2014) the retention of polyphenols in microemulsions stored at room temperature was improved by 8% compared to those stored at 40 °C after 3 months of storage. In another study, no significant differences on the antioxidant activity of curcumin loaded O/W microemulsions when stored at lower temperatures (4 or 25 °C) were observed (Amuti et al, 2021).…”

Section: Effect Of Storage On Radical Scavenging Activitymentioning

confidence: 88%

Stability of microemulsions containing red grape pomace extract obtained with a glycerol/sodium benzoate deep eutectic solvent

Alibade

Kaltsa

Bozinou

et al. 2022

OCL

View full text Add to dashboard Cite

The valorization of red grape pomace is significant as grape is one of the most cultivated fruits worldwide and generated by-product quantities are enormous. For this purpose, numerous encapsulation techniques have been developed. However, the studies on microemulsions composed with deep eutectic solvent extracts are very limited. In this study, red grape pomace extract (RGPE) was first prepared by deep eutectic solvent extraction and characterized by HPLC analysis. Rutin, quercetin, catechin and caftaric acid were identified as the main non-pigment phenolic compounds. The RGPE was further encapsulated in microemulsions (MEs) following a low-energy approach using a mixture of low molecular weight surfactants, and the pseudo-ternary phase diagram was constructed. The physical and antioxidant stability of MEs containing 3–15 wt% RGPE was investigated for a period of 30 days. MEs were stable at an ambient temperature of 25 or 37 °C. The radical scavenging activity of encapsulated RGPE was improved up to 13% compared to the free extract. Our results indicate that microemulsions provide protection of valuable phenolic constituents especially under elevated temperature conditions and can therefore be used as systems for applications in nutraceuticals or cosmetics.

show abstract

“…Encapsulation of curcumin into O/W and W/O/W microemulsions (droplet size 10–20 nm) improved its solubility, stability, and antioxidant capacity. The position of curcumin within the inner structure of microemulsions was confirmed by 1 H NMR studies [ 190 ]. Improved oral bioavailability (~2.5 times higher) was obtained after administration of curcumin-loaded turmeric oil microemulsions, with a droplet size of 29 nm in zebra fish.…”

Section: Some Common Delivery Systemsmentioning

confidence: 99%

Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena

et al. 2021

View full text Add to dashboard Cite

Toxicity caused by the exposure to human-made chemicals and environmental conditions has become a major health concern because they may significantly increase the formation of reactive oxygen species (ROS), negatively affecting the endogenous antioxidant defense. Living systems have evolved complex antioxidant mechanisms to protect cells from oxidative conditions. Although oxidative stress contributes to various pathologies, the intake of molecules such as polyphenols, obtained from natural sources, may limit their effects because of their antioxidant and antimicrobial properties against lipid peroxidation and against a broad range of foodborne pathogens. Ingestion of polyphenol-rich foods, such as fruits and vegetables, help to reduce the harmful effects of ROS, but the use of supramolecular and nanomaterials as delivery systems has emerged as an efficient method to improve their pharmacological and therapeutic effects. Suitable exogenous polyphenolic antioxidants should be readily absorbed and delivered to sites where pathological oxidative damage may take place, for instance, intracellular locations. Many potential antioxidants have a poor bioavailability, but they can be encapsulated to improve their ideal solubility and permeability profile. Development of effective antioxidant strategies requires the creation of new nanoscale drug delivery systems to significantly reduce oxidative stress. In this review we provide an overview of the oxidative stress process, highlight some properties of ROS, and discuss the role of natural polyphenols as bioactives in controlling the overproduction of ROS and bacterial and fungal growth, paying special attention to their encapsulation in suitable delivery systems and to their location in colloidal systems where interfaces play a crucial role.

show abstract

Formulation and characterization of curcumin-loaded microemulsions: Evaluation of antioxidant stability and in vitro release

Cited by 16 publications

References 44 publications

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

Preparation and evaluation of astaxanthin‐loaded 2‐hydroxypropyl‐beta‐cyclodextrin and Soluplus® nanoparticles based on electrospray technology

Stability of microemulsions containing red grape pomace extract obtained with a glycerol/sodium benzoate deep eutectic solvent

Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena

Contact Info

Product

Resources

About