Formulation and Characterization of Glibenclamide and quercetin-loaded Chitosan Nanogels Targeting Skin Permeation

Abstract

Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

Surface refined AuQuercetinnanoconjugate stimulates dermal cell migration: possible implication in wound healing

“…16,46 The opposite action of native quercetin and Au Qur NP towards the cell can be explained by absorption kinetics and bioavailability of trapped quercetin material. 47 Our data is consistent with earlier report of accelerated wound healing by quercetin loaded chitosan NPs through TGFb1-dependent mechanism, 48 and we believe it can be used as topical agent for dermal wound healing. Fig.…”

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

“…CS-embelin NPs were effective against LPO in this study. 38,39 Previous studies have reported that oxidants and LPO are negatively correlated with antioxidants. Reduced levels of cellular antioxidants and accelerated free radical production can be critical factors in arthritis.…”

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

“…89 Recently, glibenclamide-loaded chitosan nanogels have been reported as suitable topical formulations to treat diabetes with the advantage of enhanced skin permeation. 90 Hydrogels are the most studied polymeric nanocarriers as drug delivery systems, they have the advantages of higher stability in comparison with nanoemulsions and suspensions. Gelembedded vesicles are topical formulations with the advantage of skin permeation enhancement, improved dermal bioavailability, and better patient compliance.…”