Formulation and characterization of lutetium-177-labeled stannous (tin) colloid for radiosynovectomy

Abstract

Lu-Sn colloid was successfully prepared with a high LE (>95%) and high RCP (99%) under optimized reaction conditions. Because of the numerous benefits of Lu and the ease of preparation of tin colloid particles, Lu-Sn colloid particles are significantly superior to its currently available counterparts for use in radiosynovectomy.

Synthesis and Stability Studies of <sup>225</sup>Actinium Tin Colloid Radiopharmaceutical

“…In our experimental studies, temperature was kept constant since the reaction of 225 Actinium with various precursors was well performed between 90˚C -100˚C [15] [21] [31]. Recently, Arora et al [32] has successfully demonstrated that optimum labeling efficiency of 177 1). We assume that 0.18 mCi could be quite high amount of activity for the possible applications of further preclinical/clinical trials.…”