Formulation and characterization of mucoadhesive buccal films of glipizide

Semalty, Mona; Semalty, Ajay; Kumar, Ganesh

doi:10.4103/0250-474x.40330

Cited by 145 publications

(107 citation statements)

References 26 publications

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“…The number of peaks in glipizide are 15 while (GLP) 2 Ce are 4 ( fig 4. (a), (b)), thus indicating that complex formed is a well kit one.…”

Section: X-ray Diffraction Studiesmentioning

confidence: 99%

“…The X-ray pattern have been indexed by using computer software (FPSUIT 2.0V) and applying interactive trial and error method keeping in mind the characteristics of the various symmetry system, till a good fit was obtained between the observed and the calculated Sin 2 θ value. The unit cell parameters were calculated from the indexed data, from cell data and crystal lattice parameters of (GLP) 2 Ce, indicate complex attributed to Orthorhombic crystal system given in table 5.…”

Section: X-ray Diffraction Studiesmentioning

confidence: 99%

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Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Prakash¹,

Krishan²,

Jacob³

2013

Orientjchem.

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Glipizide is one of the most commonly prescribed drugs for the treatment of type 2 Diabetes mellitus 1 . It is about 100 times more potent than tolbutamide in evoking pancreatic secretion of insulin 2 . It is absorbed rapidly, uniformly with good mean oral bioavailability. It offers several advantages such as swift and short action with a very high selectivity 3-4 . It is a white or almost white crystalline, odourless powder, practically tasteless, insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. ABSTRACTGlipizide is a second generation sulphonylurea with promising hypoglycemic activity. It acts by stimulating the release of insulin from β-cells of pancreas. The present paper describes the synthesis and characterization of cerium complex with Glipizide. The conductometric titration using monovariation method reveal that complex is non-ionic and ML 2 type which was further confirmed by Job's method of continuous variation as modified by Turner and Anderson. The analytical data agree with the molecular formula (C 21 H 26 N 5 O 4 S) 2 Ce(OH 2 ) 2 , that the structure of complex was assigned as octahedral in which ligand molecules lies horizontally joining the central cerium atom. IR, NMR confirms the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. The structure of complex was proposed on the basis of analytical data, elemental analysis, IR, 1 H NMR and X-ray Diffraction studies.

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“…The number of peaks in glipizide are 15 while (GLP) 2 Ce are 4 ( fig 4. (a), (b)), thus indicating that complex formed is a well kit one.…”

Section: X-ray Diffraction Studiesmentioning

confidence: 99%

Section: X-ray Diffraction Studiesmentioning

confidence: 99%

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Prakash¹,

Krishan²,

Jacob³

2013

Orientjchem.

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show abstract

“…Samples are to be withdrawn at suitable interval replacing the same amount with fresh medium26, 27. The percentage of drug permeated can be determined by measuring the absorbance in a UV-Visible spectrophotometer [26][27].…”

Section: Permeation Studiesmentioning

confidence: 99%

Sublingual Drug Delivery: An Indication of Potential Alternative Route

Saha

Verma

Das

2017

Int J Curr Pharm Sci

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Sublingual literally meaning is "under the tongue", refers to a method of administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. Sublingual route is useful when a rapid onset of action is desired with better patient compliance than orally ingested tablets. Drugs that are given sublingually reach directly into the systemic circulation through the ventral surface of the tongue and floor of the mouth. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first-pass metabolic processes giving acceptable bioavailability. As nowadays most of the people need effective relief within a short period of time so sublingual is the most suitable form of administration. New sublingual technologies address many pharmaceutical and patient needs, ranging from enhanced life-cycle management to convenient dosing for paediatric, geriatric, and psychiatric patients with dysphagia.

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“…It was concluded that HPMC3000 at low concentrations could be useful for buccal delivery of glibenclamide in a controlled manner. [56] www.wjpps.com Vol 6, Issue 4, 2017. 398…”

Section:  Cardiovascular Diseasementioning

confidence: 99%

Buccoadhesive Drug Delivery System- A Review

Sourav¹

2017

WJPPS

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Formulation and characterization of mucoadhesive buccal films of glipizide

Cited by 145 publications

References 26 publications

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

Sublingual Drug Delivery: An Indication of Potential Alternative Route

Buccoadhesive Drug Delivery System- A Review

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