Formulation and Characterization of Mucoadhesive Polymeric Films Containing Extracts of Taraxaci Folium and Matricariae Flos

Abstract

Taraxaci folium and Matricariae flos plant extracts contain a wide range of bioactive compounds with antioxidant and anti-inflammatory effects. The aim of the study was to evaluate the phytochemical and antioxidant profile of the two plant extracts to obtain a mucoadhesive polymeric film with beneficial properties in acute gingivitis. The chemical composition of the two plant extracts was determined by high-performance liquid chromatography coupled with mass spectrometry. To establish a favourable ratio in the combination of the two extracts, the antioxidant capacity was determined by the method of reduction of copper ions Cu2+ from neocuprein and by reduction of the compound 1.1-diphenyl-2-2picril-hydrazyl. Following preliminary analysis, we selected the plant mixture Taraxaci folium/matricariae flos in the ratio of 1:2 (m/m), having an antioxidant capacity of 83.92% ± 0.02 reduction of free nitrogen radical of 1.1-diphenyl-2-2picril-hydrazyl reagent. Subsequently, bioadhesive films of 0.2 mm thickness were obtained using various concentrations of polymer and plant extract. The mucoadhesive films obtained were homogeneous and flexible, with pH ranging from 6.634 to 7.016 and active ingredient release capacity ranging from 85.94–89.52%. Based on in vitro analysis, the film containing 5% polymer and 10% plant extract was selected for in vivo study. The study involved 50 patients undergoing professional oral hygiene followed by a 7-day treatment with the chosen mucoadhesive polymeric film. The study showed that the film used helped accelerate the healing of acute gingivitis after treatment, with anti-inflammatory and protective action.

The Formulation of Dermato-Cosmetic Products Using Sanguisorba minor Scop. Extract with Powerful Antioxidant Capacities

“…However, our study found that the release percentage from emulgels, when using the cell Franz diffusion system, was the most efficient. One study investigated [65] the effects of combining Taraxaci folium and Matricariae flos plant extracts in different ratios. The aim was to create a mucoadhesive polymeric film that would have beneficial properties for treating acute gingivitis.…”

“…A 0.5 mL sample of the receptor solution was collected at different intervals of time (15 min, 30 min, 1 h, 2 h, 3 h, 4 h, 5 h, 8 h, 12 h, and 24 h) to measure the total amount of polyphenols using the Folin-Ciocalteu method. In order to ensure an even volume (6.5 mL) throughout the experiment, a new receptor medium was introduced at the specified intervals instead of using the extracted sample [64,65]. To determine the polyphenol content, the protocol involved combining 0.1 mL samples taken at various time intervals with 1.7 mL of distilled water and 0.2 mL of freshly diluted Folin Ciocâlteu reagent (1:10, v/v).…”

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

“…Oral films are novel drug delivery systems containing active ingredients in water-soluble polymer matrixes [4]. They release the drug when placed in the oral cavity by dissolving or adhering to the buccal mucosa [5]. Their action can be topical [6][7][8] or systemic [9][10][11].…”