Formulation and Characterization of Poly Sulfoxyamine Grafted Chitosan Coated Contact Lens

Abstract

Aim: The aim this research work is to formulate and characterize Poly Sulfoxyamine Grafted Chitosan Coated contact Lens.
 Methodology: Poly Sulfoxyamine Grafted Chitosan was used for coating the Lens & converting it in to Antimicrobial Lenses. Poly Sulfoxyamine Grafted Chitosan was performed in the presence of pyridine and further treatment with ammonia during reaction of Thionyl chloride & chitosan. The UV light interference, visible light transmission and antimicrobial evaluation were studied.
 Results: The results indicate that Contact lenses prepared with Modified Poly Sulfoxyamine Grafted Chitosan absorbed some UV radiation & does not interfere with visible region. Due to the antimicrobial activity of modified Chitosan, the growth and transmission of micro organisms are reduces in coated Lens as compared to uncoated Lens.
 Conclusion: On basis of the results we concluded that Modified Poly Sulfoxyamine Grafted Chitosan might be used as coating material or material for making contact Lenses which will be less susceptible for microbial contamination.

The Pharmaceutical Application of Sulfoxy Amine Chitosan in Design, Development and Evaluation of Transdermal Drug Delivery of Gliclazide

“…The surface pH value of all patches (5.6 to 6) was close to human skin pH (6.4) which means that there will be no skin irritation and therefore the patches will have good patient compliance [16,17] as the patch was intended for once-a-day application. A very high and low pH value can be harmful to the skin.…”

“…Accurately weighed 10 mg of Gliclazide was transferred to 100 ml volumetric flask and dissolved in pH 7.4 phosphate buffer and the volume was made up to 100 ml with pH 7.4 phosphate to get the final concentration of drug of 100 μg/ml [16].…”

“…Absorbance of each solution was measured by using Shimadzu UV-Vis double beam spectrophotometer at 226 nm using Phosphate buffer pH 7.4 as a reference standard. The experiment was performed in triplicate and based on average absorbance; the equation for the best line was generated [16].…”

Ocular Inserets as a Modern Therapy Trend in Opthalmopathology

“…As drying equipment in OI manugacturing can be used hydrators (Kitfort KT-1908, China) and thermostats (BINDER BD 56 Avantgarde. Linia, BINDER GmbH, Germany, JULABO GmbH, Germany) [44]. In addition to technologies that thermally affect the removal of moisture from the OI, equipment that provided a pressure function and the ability to dry inserts at low temperatures, which ensures the safety of trembling APIs for which temperature rise above zero is critical (for example, an API of biological origin), namely freeze dryers (crop, USA) and vacuum dryers (HETO CT/DV 60 e, Juan, Gidewang, Denmark, blade vacuum dryer Lödige Druvatherm®, Germany, Teclen GmbH, Germany) are also can be an optimal drying equipment [44,45].…”

“…After that the basket of the device is lowered into the vessel with liquid and explores the condition of the OI after a certain period of time. The sample is considered to be completely dissolved when there are polymers that have been totally disintegrated or there is a soft mass that is destroyed by a light touch of glass stick [44].…”