Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil

Ujilestari, Tri; Dono, Nanung Danar; Ariyadi, Bambang; Martien, Ronny; Zuprizal, Zuprizal

doi:10.11113/mjfas.v14n3.1070

Cited by 19 publications

(16 citation statements)

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“…Administration of POH decreased glucose and increased Hb levels that led to a reduction in the HbA1c levels in diabetic rats when compared to the diabetic control group. Reports have shown that agents with antioxidant and free radical scavenging properties significantly inhibit protein glycation reactions associated with DM [35] This further supports the antidiabetic effect of POH.…”

Section: Discussionsupporting

confidence: 62%

Antidiabetic Potential of Perillyl Alcohol, a Monoterpene on High-Fat Diet Low-Dose Streptozotocin-Induced Diabetes in Experimental Rats

Hassan

Elanchezhiyan

Naseer

2019

Asian J Pharm Clin Res

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Objective: The aim of the study was to evaluate the antidiabetic potential of Perillyl alcohol (POH) in high-fat diet (HFD) and low-dose streptozotocin (STZ)-induced diabetic Wistar rats. Methods: In experimental rats fed with HFD for 4 weeks, diabetes was induced by single intraperitoneal injection of STZ (35 mg/kg body weight [BW]). Three days after STZ induction, the hyperglycemic rats were treated with POH orally at the doses of 50 and 100 mg/kg BW daily for 30 days. Glibenclamide (6 mg/kg BW) was used as reference drug. Blood glucose level, BW, fluid intake, and food intake such as parameters were analyzed throughout the experiment period. Serum and plasma biochemical parameters were also estimated. Assay on insulin resistance was also done. Histological study of the pancreas and liver was also performed. Results: POH orally at the doses of 50 and 100 mg/kg BW for 30 days significantly (p<0.05) and dose-dependently reduced and normalized blood glucose levels as compared to that of HFD+STZ control group. Serum and plasma parameters were significantly (p<0.05) restored toward the normal levels in POH-treated rats as compared to HFD-STZ control animals. Histological study of liver and pancreas also shows the prominent regeneration in POH and glibenclamide treated rats. Conclusion: The present study concludes that POH demonstrated promising antidiabetic action in HFD STZ-induced diabetic rats.

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Section: Discussionsupporting

confidence: 62%

Antidiabetic Potential of Perillyl Alcohol, a Monoterpene on High-Fat Diet Low-Dose Streptozotocin-Induced Diabetes in Experimental Rats

Hassan

Elanchezhiyan

Naseer

2019

Asian J Pharm Clin Res

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“…Drug delivery facilitated by SEDDSs are essentially influenced by droplet size, droplet size distribution and zeta-potential [ 41 , 63 , 64 ]. Size characterization is considered one of the most insightful experiments performed during the development of SEDDSs as size influences not only drug release, but also the stability of the SEDDS formulations [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

2020

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A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and water-titration experiments identified spontaneous emulsification capacity of different excipient combinations and clofazimine. After identifying self-emulsification regions, check-point formulations were selected within the self-emulsification region by considering characteristics required to achieve optimized topical drug delivery. Check-point formulations, able to withstand phase separation after 24 h at an ambient temperature, were subjected to characterization studies. Experiments involved droplet size evaluation; size distribution; zeta-potential; self-emulsification time and efficacy; viscosity and pH measurement; cloud point assessment; and thermodynamic stability studies. SEDDSs with favorable properties, i.e., topical drug delivery, were subjected to dermal diffusion studies. Successful in vitro topical clofazimine delivery was observed. Olive oil facilitated the highest topical delivery of clofazimine probably due to increased oleic acid levels that enhanced stratum corneum lipid disruption, followed by improved dermal clofazimine delivery. Finally, isothermal microcalometric experiments studied the compatibility of excipients. Potential interactions were depicted between argan oil and clofazimine as well as between Span®60 and argan-, macadamia- and olive oil, respectively. However, despite some mundane incompatibilities, successful development of topical SEDDSs achieved enhanced topical clofazimine delivery.

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“…Along with the formula generated in our previous study [26], SNEDDS were optimized using a D-Optimal mixture experimental designed and performed using a Design Expert® Ver. 7.1.5. software (Stat-Ease Inc., Minneapolis, USA) [27] by selecting the percentage of the oil component X1 (a mixture of VCO and Cymbopogon citratus essential oil), the surfactant X2 (Tween 80), and the co-surfactant (PEG 400) as independent variables, while emulsification time in sec (Y1) and transmittance in percent (Y2) as responses.…”

Section: Optimization Of Sneddsmentioning

confidence: 99%

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

et al. 2019

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Objective: Focus of this study was to optimize and to characterize the self-Nano emulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17±0.06 nm, 0.17±0.05,-20.90±1.47 mV, 200±0mPa. s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test; meanwhile, transmission electron microscopy displayed spherical shape.Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.

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Formulation and characterization of self-nano emulsifying drug delivery systems of lemongrass (cymbopogon citratus) essential oil

Cited by 19 publications

References 0 publications

Antidiabetic Potential of Perillyl Alcohol, a Monoterpene on High-Fat Diet Low-Dose Streptozotocin-Induced Diabetes in Experimental Rats

Antidiabetic Potential of Perillyl Alcohol, a Monoterpene on High-Fat Diet Low-Dose Streptozotocin-Induced Diabetes in Experimental Rats

Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

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