Formulation and Characterization of Solid Dispersions of Etoricoxib Using Natural Polymers

Sapkal, Sandip Babarao; Adhao, Vaibhav S.; Thenge, Raju; Darakhe, Rahul Ashok; Shinde, Sushilkumar Ananda; Shrikhande, Vinayak N.

doi:10.4274/tjps.galenos.2018.04880

Cited by 17 publications

(11 citation statements)

References 8 publications

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“…Literature also supports the enhancement of solubility of solid dispersions is better with the hydrophilic carrier PVP K30 than the PEGs by the solvent method. This improved solubility can be attributed to the solubilization effect of the carrier, which increases the wetting property of the drug [14].…”

Section: Resultsmentioning

confidence: 99%

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Formulation of Solid Dispersions for Enhancement of Solubility and Dissolution Rate of Simvastatin

Borawake¹,

Kauslya²,

Shinde³

2021

Int J Pharm Pharm Sci

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Objective: The objective of the present work was to formulate the solid dispersions of simvastatin for enhancement of its aqueous solubility and dissolution rate. Methods: In the present study, solid dispersions of simvastatin were prepared by Kneading and Solvent evaporation methods. The polymeric carriers like Polyethylene glycol (PEG) 6000 and Polyvinyl Pyrrolidone (PVP) K30 were used in different ratios (ratio of drug: carrier was 1:1, 1:2) to formulate solid dispersions. The prepared solid dispersions were characterized by differential scanning calorimetry (DSC), Fourier transforms infrared spectroscopy (FTIR), and evaluated for drug content, percentage yield, saturation solubility, in vitro dissolution studies. The best formula of the solid dispersion was selected according to the solubility and dissolution data. Results: The F7 formulation was found to be an optimized formulation containing PVP K30 in the ratio 1:1 prepared by solvent evaporation technique. The Drug content was found to be higher i.e. 94.89 in the F7 batch. The FT-IR spectra revealed that there was no interaction between drugs and carriers. DSC thermogram indicated entrapment of simvastatin in PVP K30 and the conversion of crystalline simvastatin into an amorphous form. The F7 formulation showed maximum drug release i.e. 98.60% in 60 min which is 2 times greater than pure drug making it an optimized formulation. Conclusion: The solubility of simvastatin was successfully enhanced through the solid dispersion technique. Solid dispersions prepared with solvent evaporation method were more soluble than solid dispersions prepared with kneading method with carrier PVP K30.

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Section: Resultsmentioning

confidence: 99%

“…By using FT-IR Spectrophotometer (FT-IR 8400S, Shimadzu), compatibility studies of drugs and carriers were carried out. FTIR spectra of SDs and physical mixture were obtained by the potassium bromide method in which powder is scanned in the range of 4000-400 cm -1 with resolution 1 cm -1 DSC analysis [14].…”

Section: Fourier Transform Infrared Spectroscopymentioning

confidence: 99%

Formulation of Solid Dispersions for Enhancement of Solubility and Dissolution Rate of Simvastatin

Borawake¹,

Kauslya²,

Shinde³

2021

Int J Pharm Pharm Sci

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“…Solid dispersions from each formulation containing amlodipine besylate equivalent to 20 mg were obtained and dissolved using ethanol in a 100 ml volumetric flask which was then filtered. The filtered solution was then diluted suitably and the drug content of the solid dispersions were analyzed using UviLine 9400 Spectrophotometer AHS Laboratory Supplies, Malaysia (7).…”

Section: Drug Content Uniformitymentioning

confidence: 99%

Comparison of Microemulsion and Solvent Evaporation Technique for Solubility Enhancement of Amlodipine Besylate

Hamzah¹,

Ming²,

Uddin³

et al. 2022

MJMHS

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Introduction: Amlodipine besylate is a calcium channel blocker indicated for hypertension and angina. It is described as slightly soluble in water and due to its limited solubility, it may result in poor bioavailability. The aim of this study is to enhance the solubility of amlodipine besylate using solvent evaporation method and microemulsion technique and to compare the two methods. Method: Solid dispersions (SD) of amlodipine besylate were developed by employing solvent evaporation method. PEG6000 was the polymer of choice and different drug:polymer ratios were used. Evaluation of the prepared SDs include solubility studies, dissolution studies and scanning electron microscopy (SEM). As for the microemulsion technique, microemulsions were prepared by phase titration method and the optimized microemulsion formulation was then characterized for solubility studies and dissolution studies. Results: SD3 with drug:polymer ratio of 1:4 achieved the highest solubility which was 96.97 mg/ml ± 0.92 whereas the solubility of the optimized microemulsion was found to be 112.54 mg/ml ± 0.92. In solvent evaporation method, as the drug:polymer ratio increases, the solubility and dissolution rate of SDs increases. Conclusion: The two methods had significantly enhance the solubility of amlodipine besylate however the microemulsion technique showed better solubility profile.

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“…ASDs have been made to serve as solid cores encapsulated within protein microcapsules [12,21]. ASDs of various drugs have also been made in composition with a variety of natural polymers, such as gaur gum, xanthan gum, and acacia [38]. The encapsulation of ASDs in hydrophilic capsules also ensures the enhanced bioavailability of the cargo.…”

Section: Desired Functionsmentioning

confidence: 99%

Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review

2021

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Natural polymers, such as polysaccharides and polypeptides, are potential candidates to serve as carriers of biomedical cargo. Natural polymer-based carriers, having a core–shell structural configuration, offer ample scope for introducing multifunctional capabilities and enable the simultaneous encapsulation of cargo materials of different physical and chemical properties for their targeted delivery and sustained and stimuli-responsive release. On the other hand, carriers with a porous matrix structure offer larger surface area and lower density, in order to serve as potential platforms for cell culture and tissue regeneration. This review explores the designing of micro- and nano-metric core–shell capsules and porous spheres, based on various functions. Synthesis approaches, mechanisms of formation, general- and function-specific characteristics, challenges, and future perspectives are discussed. Recent advances in protein-based carriers with a porous matrix structure and different core–shell configurations are also presented in detail.

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Formulation and Characterization of Solid Dispersions of Etoricoxib Using Natural Polymers

Cited by 17 publications

References 8 publications

Formulation of Solid Dispersions for Enhancement of Solubility and Dissolution Rate of Simvastatin

Formulation of Solid Dispersions for Enhancement of Solubility and Dissolution Rate of Simvastatin

Comparison of Microemulsion and Solvent Evaporation Technique for Solubility Enhancement of Amlodipine Besylate

Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review

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