Formulation and Characterization of Terbinafine Emulgel for Superficial Fungal Infections

Arora, Ritika; Khan, Rukhsar; Ojha, Anup; Chopra, Himansu; Upadhyaya, Kumud

doi:10.5958/0974-360x.2018.00917.4

Cited by 5 publications

(7 citation statements)

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“…It is also used traditionally in the treatment of parasitic infections of the intestine and other digestive problems, manufacturing fragrance, and improving food stability due to its antioxidant activity [65]. Research has identified a potential role for clove oil in enhancing the permeation of different drugs intended to be administered topically [61,66,67].…”

Section: Clove Oilmentioning

confidence: 99%

“…This might be a reason for combining clove oil with other penetration enhancers or incorporating it in only certain formulations. For instance, clove oil exhibits synergistic effects when combined with Tween 80 [70] and peppermint oil [66] in enhancing the permeation of aceclofenac and terbinafine, respectively. In addition, clove oil produces a synergistic effect on the permeation of felodipine [61] when incorporated into niosomes.…”

Section: Clove Oilmentioning

confidence: 99%

“…It has various purported therapeutic activities such as relieving gastric upset, toothache, headache, nausea, and muscle spasm. It has also shown promising potential in enhancing the dermal and transdermal permeation of different drugs [66,67,85].…”

Section: Peppermint Oilmentioning

confidence: 99%

“…Peppermint oil has promising pharmaceutical potential and has been used as a penetration enhancer in dermal dosage forms, including in a gel [18,66] and cream [86], as well as transdermal dosage forms such as microemulsions [67] and liposomes [85]. An in vitro permeation study found it to increase the penetration of lopinavir as compared to olive oil [85].…”

Section: Peppermint Oilmentioning

confidence: 99%

“…Moreover, Zhang et al [18] reported peppermint oil's ability to increase the penetration of phentolamine more effectively than Transcutol P ® , Labrasol ® , SDS, polyethylene glycol, Pharmasolve ® , and oleic acid [18]. As well as the superiority of peppermint oil over clove oil in enhancing the permeation of quercetin through the skin from a microemul-sion [67], peppermint oil combined with clove oil in an emulgel formulation enhances the permeation of terbinafine synergistically [66]. In addition, peppermint oil is more effective than orange terpeneless oil and is comparable to ethanol 75%, as well as DMSO's effect in enhancing penetration of calcium thioglycolates and eventually decreasing tear-resistant time (TRT).…”

Section: Peppermint Oilmentioning

confidence: 99%

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Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

2022

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Oils, including essential oils and their constituents, are widely reported to have penetration enhancement activity and have been incorporated into a wide range of pharmaceutical formulations. This study sought to determine if there is an evidence base for the selection of appropriate oils for particular applications and compare their effectiveness across different formulation types. A systematic review of the data sources, consisting of Google Scholar, EMBASE, PubMed, Medline, and Scopus, was carried out and, following screening and quality assessment, 112 articles were included within the analysis. The research was classified according to the active pharmaceutical ingredient, dosage form, in vitro/in vivo study, carrier material(s), penetration enhancers as essential oils, and other chemical enhancers. The review identified four groups of oils used in the formulation of skin preparations; in order of popularity, these are terpene-type essential oils (63%), fatty acid-containing essential oils (29%) and, finally, 8% of essential oils comprising Vitamin E derivatives and miscellaneous essential oils. It was concluded that terpene essential oils may have benefits over the fatty acid-containing oils, and their incorporation into advanced pharmaceutical formulations such as nanoemulsions, microemulsions, vesicular systems, and transdermal patches makes them an attractive proposition to enhance drug permeation through the skin.

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Section: Clove Oilmentioning

confidence: 99%

Section: Clove Oilmentioning

confidence: 99%

Section: Peppermint Oilmentioning

confidence: 99%

Section: Peppermint Oilmentioning

confidence: 99%

Section: Peppermint Oilmentioning

confidence: 99%

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Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

2022

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Development and Evaluation of Celecoxib Emulgel by Using Natural Oil

Rajput,

Gaur,

Kulshreshtha

et al. 2024

AIAAMC

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Background: Emulgel combines the qualities of an emulsion with those of a gel. In order to create an emulgel w/o or o/w, emulsions have to be formulated, which are then com-bined with a gelling agent, resulting in a dual-control drug release. Celecoxib exhibits analge-sic, antipyretic and anti-inflammatory activities and is used to treat osteoarthritis, severe pain, rheumatoid arthritis, and other medical conditions. Methods: Celecoxib Emulgel was developed and evaluated by using natural oil and carbopol-940 as a gelling agent in different concentrations. The screening of various oils, co-surfactants and surfactants was performed to determine the solubility. The essential oils (eucalyptus oil and turpentine oil) were used as penetration modifiers. Studies on compatibility with polymers have been conducted, and the results indicate that there should be no physical or chemical interactions between the polymers and the drug substance. For the preparation of emulgel, various emulsions were prepared with Smix (cosurfactant and surfactant) ratios (1:1, 2:1 and 3:1). The selection of a gelling agent was done by incorporating the selected emulsion system ratio of 1:1 with the combinations of polymers carbapol 940, carbapol 934, and HPMC (0:1:0, 0:0.5:1, 0:0:3, 0.5:0:1, 1:0:0) gel base to make a homogenous emulgel. Results: The emulgel was examined visually to see if it had any phase behaviour, feel, spread-ability, and grittiness by applying its thin layer to a slide. Then, all six formulations of emulgel were prepared with the selected gelling agent. All emulgels were evaluated for pH, physical properties (consistency, homogeneity, colour, texture), drug content, spreadability, extrudabil-ity, swelling index, viscosity, stability and centrifugation. A Franz diffusion cell and an egg membrane were used to perform in-vitro drug release. Conclusion: Among all prepared formulations, EG1 had a better release, higher viscosity, higher drug content, and a higher swelling index than the others. The formulation EG1 showed higher drug release (91.25%) within 8 hours.

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An overview of emulgels for topical application

Jabbar

Ali

2023

AJPS

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In recent years, gels have been preferentially used for cosmetics and topical pharmaceutical preparations due to their favorable characteristics, such as being greaseless, readily spreadable and easily removable. However, one obstacle that faced it was the inability to enclose hydrophobic compounds. Therefore, a novel approach was developed to circumvent this limitation by mixing the gel with an emulsion, which led to creation of a new topical drug delivery system known as emulgel. Emulgel preserves all favorable features of gel and provides also dual release for drug, thus can be utilized effectively in controlling release and absorption of medication after topical application. Emulgel preparation requires coherent steps, this includes preparation of emulsion and gel and determining their mixing ratio. Finally, the prepared emulgels should be evaluated to ensure their suitability and efficacy for the topical application.

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Formulation and Characterization of Terbinafine Emulgel for Superficial Fungal Infections

Cited by 5 publications

References 0 publications

Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

Development and Evaluation of Celecoxib Emulgel by Using Natural Oil

An overview of emulgels for topical application

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