Formulation and Development of Ketoprofen Bilayer Tablets

Abstract

Aim of present research work was formulation and development of bilayer tablets of Ketoprofen to reduce the side effects of Ketoprofen and to improve the therapeutic benefits and patients' compliance to treatment. Bi-layer tablets of Ketoprofen were prepared by direct compression technique using excipients like MCC, superdisintegrant, aspartame, colour agent were mixed properly shifted from sieve no 40. Before compression; add talc magnesium stearate mixed it well. Formulations with optimal properties have been selected to obtain bi-layer tablets of adequate quality. The in vitro dissolution study of the prepared bilayer tablets showed a controlled release of active drugs over a period of 24 hours.