Formulation and Development of Tropicamide Loaded Solid Lipid Nanoparticles Enriched in Chitosan in-Situ Gels for Ocular Drug Delivery

Ramesh, Yerikala; Kothapalli, Chandrasekhar B.; Reddigari, Jayachandra Reddy Peddappi

doi:10.22270/jddt.v7i6.1566

Cited by 7 publications

(8 citation statements)

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“…The UV-Visible spectra were recorded after 18hrs from the initiation of the reaction in which the absorption maxima was scanned from 300 to 700 nm [6]. The sample was analyzed by its maximum absorbance v/s wavelength to con irm the formation of AgNPs.…”

Section: Characterization Of Silver Nanoparticles Uv-vis Spectroscopymentioning

confidence: 99%

Formulation and Characterization of Anti-Bacterial Activity of Silver Nanoparticles Using Root and Leaf of Wedelia trilobata

Prakash¹

2021

Fut J. Pharm & H. Sci

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In the present study one such species, Wedelia trilobata, has be chosen to review the In vitro antibacterial activity of the root extract by using solvent ethanol for the selected plant Wedelia triolobata. The deduction of nanoparticles used to be unalterable by UV-Visible spectroscopy, FTIR, particle size, and zeta potential. The anti-bacterial activity of Wedelia trilobata mediated synthesis silver nanoparticles was tested by disc diffusion assay against standard organisms like Escherichia coli and staphylococcus aureus bacteria. The formation of silver nanoparticles by Wedelia trilobata was initially demonstrated by color changes confirmed by UV-Visible root exhibited a specific absorbance peak around 450 nm and leaf exhibited a specific absorbance peak around 418nm respectively. The Zeta potential of silver nanoparticles was found to be root 0.1 and leaf 0.4, so it indicates the dispersion and stability. The antibacterial activity against Gram-positive Staphylococcus aureus was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (9.5Mm), standard (12.3Mm), control (11.3Mm), extraction for AgNPs Wedelia trilobata (13.8). 5Mm for normal (7.3Mm), standard (19.4Mm), control (10.5Mm), extraction for AgNPs Wedelia trilobata (19.8). The antibacterial activity against Gram-negative E.coli was increased, which was indicated by an increase in the inhibition zone diameter from 3Mm for normal (7.8Mm), standard (8.5Mm), control (10.2Mm), extraction for AgNPs Wedelia trilobata (14.3). 5Mm for normal (13Mm), standard (19.6Mm), control (15.3Mm) extraction for AgNPs Wedelia trilobata (19.8). The present investigation revealed that the ethanolic Root and aqueous leaf extracts the chosen plant have potential to suppress the expansion of infective bacterial strains.

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Section: Characterization Of Silver Nanoparticles Uv-vis Spectroscopymentioning

confidence: 99%

Formulation and Characterization of Anti-Bacterial Activity of Silver Nanoparticles Using Root and Leaf of Wedelia trilobata

Prakash¹

2021

Fut J. Pharm & H. Sci

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“…It becomes done beneath luorescent light opposed to a white and black backdrop for the reason that presence containing any particulate matter [5].…”

Section: Evaluation Of Formulation Visual Appearance and Claritymentioning

confidence: 99%

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Injeti¹

2021

Int. J. Clin. Pharm. Med. Sci.

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“…6. Miscellaneous: Ocular penetration, Ocular iontophoresis, Vesicular dosage forms, Mucoadhesive systems [10].…”

Section: Parenteral Preparationsmentioning

confidence: 99%

Conventional Opthalamic Drug Delivery System: An Outlook

Prakash¹

2021

Fut J. Pharm & H. Sci

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The most sensitive and complex organ in the human body is the eye, so special attention should be needed for the administration of pharmaceutical substances into the eye. It is one of the most difficult for researchers in the preparation of drug delivery to the eye. The anatomical characteristics and physiological properties of the eye should be considered in drug delivery. The properties of pharmaceutical dosage forms depend upon the anatomy and physiology of the eye. Drug delivery on to the outer part as well as in the inner part of the ocular structure for the therapy is a unique and challenging one. Physiochemical, microbiological, and pharmaceutical properties lead to absorption and elimination of active therapeutic agents into and out of the eye. Loss of precorneal more and fastly occurs due to drainage in the region of extraocular are some of the drawbacks in ocular drug delivery of conventional dosage forms. To overcome these problems, advancements in conventional dosage forms take place.

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Formulation and Development of Tropicamide Loaded Solid Lipid Nanoparticles Enriched in Chitosan in-Situ Gels for Ocular Drug Delivery

Cited by 7 publications

References 0 publications

Formulation and Characterization of Anti-Bacterial Activity of Silver Nanoparticles Using Root and Leaf of Wedelia trilobata

Formulation and Characterization of Anti-Bacterial Activity of Silver Nanoparticles Using Root and Leaf of Wedelia trilobata

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Conventional Opthalamic Drug Delivery System: An Outlook

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