Formulation and evaluation of an Anti-pyretic (Paracetamol) syrup for Paediatric

Abstract

Available online on:15.01.2018@http://ijrdpl.co m http://dx.doi.org/10.21276/ IJRDPL. 2278-0238.2018.7(1).2924-2930 ABSTRACT: Background: Studies suggested that fever may have a beneficial for safe drug delivery. The use of paracetamol in therapeutic doses generally is safe, although hepatotoxicity has occurred with recommended dosages in children. Material and Method: home storage conditions at a temperature ranging from (2-8 °C) representing refrigerator and accelerated condition. Prepare a solvent mixture consisting of 0.4 volumes of formic acid, 15 volumes of methanol and 85 volumes of water. Result: Evaluated prepared 4 formulations the physical description (Color, odor, and taste) were found colorless, none and sweet. The pH of F1, F2, F3, and F4 was found 5.39,5.16,5.09 and 5.04. In these four formulations, we were selected F1 on the behalf of best pH. The F1 formulation weight per ml was found 1.0312 gm/ml. the assay of paracetamol syrup F1 formulation was found 99.88%. The stability of four formulations was found 5.36,5.16,5.08 and 5.03 Conclusion: It was concluded that F1 formulation was good and stabilized formulation. Like syrup formulations made by use of a combination of physiologically compatible mixed solubilizes. The proposed mixed solubilizes are known to be safe; hence, toxicities/safety related issues may not raise concern, suggesting the adaptability for large-scale manufacturing i.e. industrial feasibility.

Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations

“…The paracetamol syrup was prepared as described by Singh et al [ 17 ]. A mass of 2400 mg of paracetamol powder was weighed accurately into a separate beaker, and 5 mL of ethanol (96%) was added and stirred for 45 minutes.…”

Ibuprofen syrup made by mixed solubilization technique

“…a) Physical Properties (Li, Roos, and Miao 2017) Appearance: Clear and Transparent b) Determination of pH (Singh, Kumar, and Prasad 2018) The acidity or alkalinity of an aqueous solution is traditionally represented by the pH value. The glass electrode was used to determine the pH value of a solution potentiometrically.…”

Sensitive and selective determination of paracetamol in antipyretic children's syrup with a polyglycine modified glassy carbon electrode

“…Because of the easy public availability of this drug, it has been repeatedly associated with potentially fatal overdoses. 2,[4][5][6][7][8][9][10] However, paracetamol overdose or hypersensitivity can lead to increased formation of nephrotoxic intermediate metabolites, especially N-acetyl-p-benzoquinone imine. 2,11 This results in symptoms such as headache, nervousness, liver failure, restlessness, nausea, rashes, seizures, insomnia, kidney damage, tremors, and pancreatic inammation.…”