Formulation and Evaluation of Aripiprazole Oro-Dispersible Tablets: Optimisation Through Factorial Design of Experiments

Abstract

The main objective of this study was to prepare and evaluate fast dissolving tablets of aripiprazole using three different types of superdisintegrants. Various formulations were prepared by direct compression using different concentrations of superdisintegrant i.e. namely Kyron T-104, Kyron T-154 and Kyron T-314. The compatibility studies between drug and excipients were carried out using Fourier Transform Infrared spectroscopy. The blend was evaluated for additive properties. The tablets formulated using factorial design was evaluated for physical properties and in-vitro drug release. From this study formulation containing Kyron T-154 was found to possess better disintegration time of 15 sec, water absorption ratio (77.5 %), and wetting time (22.7 sec) with taste masking property at low concentration and hence formulation containing was Kyron T-154 optimized.

Formulation and evaluation of herbal tablet containing Terminalia chebula extract

“…Tapped density was determined by pouring the accurately weighed quantity of powder blend into the graduate cylinder and the volume (V) was measured. Then the graduated cylinder was closed with lid, and tapped by using bulk density apparatus till a constant volume was maintained in the cylinder [10]. The tapped density was calculated by using given equation.…”