Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel

Alshehri, Sultan; Imam, Syed Sarim

doi:10.1080/10717544.2021.1995078

Cited by 17 publications

(8 citation statements)

References 42 publications

(46 reference statements)

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“…It is slightly soluble in water and readily soluble in organic solvents. There are different BN-loaded nanoformulations: PLGA-NP-laden chitosan nano-gel and NLCs-based gel were prepared and evaluated for different parameters [ 20 , 21 ]. They have reported prolonged drug release and enhanced drug permeation and retention with antifungal activity.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Topical Nano-Lipid-Based Delivery of Butenafine: In Vitro Characterization and Antifungal Activity

Zafar

Imam

Alruwaili

et al. 2022

Gels

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The present research work was designed to prepare butenafine (BN)-loaded bilosomes (BSs) by the thin-film hydration method. BN is a sparingly water-soluble drug having low permeability and bioavailability. BSs are lipid-based nanovesicles used to entrap water-insoluble drugs for enhanced permeation across the skin. BSs were prepared by the thin-film hydration method and optimized by the Box–Behnken design (BBD) using lipid (A), span 60 (B), and sodium deoxycholate (C) as independent variables. The selected formulation (BN-BSo) was converted into the gel using Carbopol 940 as a gelling agent. The prepared optimized gel (BN-BS-og) was further evaluated for the gel characterization, drug release, drug permeation, irritation, and anti-fungal study. The optimized bilosomes (BN-BSo) showed a mean vesicle size of 215 ± 6.5 nm and an entrapment efficiency of 89.2 ± 1.5%. The DSC study showed that BN was completely encapsulated in the BS lipid matrix. BN-BSog showed good viscosity, consistency, spreadability, and pH. A significantly (p < 0.05) high release (81.09 ± 4.01%) was achieved from BN-BSo compared to BN-BSog (65.85 ± 4.87%) and pure BN (17.54 ± 1.37 %). The permeation study results revealed that BN-BSo, BN-BSog, and pure BN exhibited 56.2 ± 2.7%, 39.2 ± 2.9%, and 16.6 ± 2.3%. The enhancement ratio of permeation flux was found to be 1.4-fold and 3.4-fold for the BN-BS-og and pure BN dispersion. The HET-CAM study showed that BN-BSog was found to be nonirritant as the score was found within the limit. The antifungal study revealed a significant (p < 0.05) enhanced antifungal activity against C. albicans and A. niger. The findings of the study revealed that BS is an important drug delivery system for transdermal delivery.

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Topical Nano-Lipid-Based Delivery of Butenafine: In Vitro Characterization and Antifungal Activity

Zafar

Imam

Alruwaili

et al. 2022

Gels

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“…After determining the viscosity of the gel, a satisfactory spreadability value was obtained. The excellent viscosity and spreadability of the topical gel allow easy application of a layer to the skin, as also reported in the literature [ 34 ].…”

Section: Resultsmentioning

confidence: 65%

Herbal Fennel Essential Oil Nanogel: Formulation, Characterization and Antibacterial Activity against Staphylococcus aureus

Alam

Foudah

Salkini

et al. 2022

Gels

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Antimicrobial resistance (AMR) is one of the greatest threats to humanity in the world. Antibiotic-resistant bacteria spread easily in communities and hospitals. Staphylococcus aureus (S. aureus) is a serious human infectious agent with threatening broad-spectrum resistance to many commonly used antibiotics. To prevent the spread of pathogenic microorganisms, alternative strategies based on nature have been developed. Essential oils (EOs) are derived from numerous plant parts and have been described as antibacterial agents against S. aureus. Fennel essential oils were selected as antibacterial agents encapsulated in nanoparticles of polylactic acid and glycolic acid (PLGA). The optimum size of the formulation after loading with the active ingredient was 123.19 ± 6.1595 nm with a zeta potential of 0.051 ± 0.002 (23 ± 1.15 mV). The results of the encapsulation efficiency analysis showed high encapsulation of EOs, i.e., 66.4 ± 3.127. To obtain promising carrier materials for the delivery of fennel EOs, they were incorporated in the form of nanogels. The newly developed fennel oils in PLGANPs nanogels have good drug release and MIC against S. aureus. These results indicate the potential of this novel delivery system for antimicrobial therapy.

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“…The entrapment efficiency was determined by ultra-centrifuged at 15,000 rpm for 15 min at 4 °C in a cooling centrifuge (REMI). After centrifugation, the supernatant containing the free drug was separated and estimated using a UV–visible spectrophotometric method at 218 nm ( Alshehri and Imam, 2021 ). The biodegradability study was evaluated by placing 10 mg (PEG-MEM-PLGA) SANs in 4 mg lysozyme/ml solution in PBS (pH = 7.4) incubated at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds

Rani

Verma

Kumar

et al. 2023

Current Research in Pharmacology and Drug Discovery

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Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel

Cited by 17 publications

References 42 publications

Formulation and Evaluation of Topical Nano-Lipid-Based Delivery of Butenafine: In Vitro Characterization and Antifungal Activity

Formulation and Evaluation of Topical Nano-Lipid-Based Delivery of Butenafine: In Vitro Characterization and Antifungal Activity

Herbal Fennel Essential Oil Nanogel: Formulation, Characterization and Antibacterial Activity against Staphylococcus aureus

Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds

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