Formulation and Evaluation of Carbamazepine 200 mg Controlled Release Tablets Using Different HPMC Grades

Ali, Wael

doi:10.9734/bjpr/2013/3923

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…Carbamazepine controlled release tablets were also developed with polymers such as HPMC of various grades, using the wet granulation technique and some using the direct compression method. They found that the drug was efficiently extended by HPMC [ 9 ]. Glipizide controlled release matrices were prepared by direct compression technique and used Eudragit and HPMC as polymers, and evaluated its physicochemical characteristics and noted that drug release was extended [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents

Khan

Muzammal

et al. 2022

Molecules

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Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method was adopted for the preparation of matrices. In phosphate buffer (pH 6.8), the dissolution study was conducted by adopting the USP method-I as the specified method. Drug release kinetics was determined and dissolution profiles were also compared with the reference standard. Prolonged release was observed for all matrices, but those with Ethocel 100FP Premium showed more extended release. The co-excipient (HPMC, CMC, and starch) exhibited enhancement in the drug release rates, while all controlled release matrices released the drug by anamolous non-Fickian diffusion mechanism. This combination of polymers (Ethocel grade 100 with Carbopol 934PNF) efficiently extended the drug release rates up to 24 h. It is suggested that these matrix tablets can be given in once a day dosage, which might improve patient compliance, and the polymeric blend of Ethocel grade 100 with Carbopol 934PNF might be used in the development of prolonged release matrices of other water-soluble drugs.

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Section: Introductionmentioning

confidence: 99%