Generation of 1:1 Carbamazepine:Nicotinamide cocrystals by spray drying

Screening and characterization of cocrystal formation between carbamazepine and succinic acid

“…Pharmaceutical technology is aiming nowadays in developing new formulations in order to improve the dissolution behavior, stability, mechanical and wetting properties and bioavailability, respectively [3][4][5]. These improvements can be achieved both by developing new final formulations by appropriate selection of excipients and by obtaining crystalline solids composed of an active substance and a conformer, or of two active substances [6,7].…”

Challenge of the supercritical antisolvent technique SAS to prepare cocrystal-pure powders of naproxen-nicotinamide

“…The cocrystal fabrication is mostly based on conventional crystallization techniques, such as evaporative and cooling crystallization [7,8], grinding [7,8] slurrying [9] although more original ways such as continuous melt extrusion [10,11], high pressure homogenization [12] or coupling chemical synthesis and cooling [13] are now considered. Some of these techniques are carried out for screening purposes but for large scale production, cocrystallization from solution as spray-drying [14,15], solutions mixing [16], isothermal suspension conversion [17] or antisolvent precipitation [18] may offer more viable routes of fabrication.…”

Processing Paracetamol-5-Nitroisophthalic Acid Cocrystal Using Supercritical Co2 as an Anti-Solvent

“…In addition, remaining solvent residues may contaminate the product, and the production of mechanical stress and heat evolution during the grinding process can affect the thermal degradation of the components. Therefore, the development of novel and better methods for the screening and production of cocrystals is highly desirable [16][17][18].…”