The pharmaceutical cocrystals are nowadays studied due to the fact that several properties, such as solubility, stability, dissolution rate and bioavailability, can be modulated. In this work, a cocrystal containing carbamazepine (CBZ) and succinic acid (SA) were prepared by the cogrinding method of the active substances, following the subjection of the physical mixture to microwave irradiation. The formation and stability of CBZ-SA cocrystal were explored using thermoanalytical methods (TG/ DTG/HF), Fourier transform infrared spectroscopy and PXRD pattern diffraction. The preparation of the cocrystal was realized by slow evaporation of solvent (ethanol) from the mixture which contained the active substances in molar ratio CBZ:SA = 2:1.

The importance of developing new pharmaceutical final formulations is nowadays well known. In this paper, we present the study of compatibility between bioactive antihyperlipidemic agent simvastatin and eight currently used pharmaceutical excipients for developing solid dosage forms, namely starch, microcrystalline cellulose, lactose monohydrate, polyvinylpyrrolidone, colloidal silica, talc, magnesium citrate and sorbitol. The compatibility investigations were carried out under ambient temperature by FTIR spectroscopy studies and PXRD patterns and then completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures.

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Background. Both 1,2,3-and 1,2,4-triazoles are nowadays incorporated in numerous antibacterial pharmaceutical formulations. Aim. Our study aimed to prepare three substituted 1,2,4-triazoles and to evaluate their antibacterial properties. Materials and Methods. One disubstituted and two trisubstituted 1,2,4-triazoles were prepared and characterised by physical and spectroscopic properties (melting point, FTIR, NMR, and GC-MS). The antibacterial properties were studied against three bacterial strains: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853), by the agar disk diffusion method and the dilution method with MIC (minimal inhibitory concentration) determination. Results. The spectroscopic characterization of compounds and the working protocol for the synthesis of the triazolic derivatives are described. The compounds were obtained with 15-43% yields and with high purities, confirmed by the NMR analysis. The evaluation of biological activities showed that the compounds act as antibacterial agents against Staphylococcus aureus (ATCC 25923), while being inactive against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Conclusions. Our results indicate that compounds containing 1,2,4-triazolic moiety have great potential in developing a wide variety of new antibacterial formulations.

This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.