Formulation and evaluation of drug-free ophthalmic films prepared by using various synthetic polymers

H, Patel Dipti; P, Patel Manish; Madhabhai, M Patel

doi:10.4103/0975-1483.55742

Cited by 14 publications

(7 citation statements)

References 2 publications

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“…The amount of glycerol used in the present study was much less than that in the literature, where much higher concentrations of glycerol were used to prepare films for various purposes [39][40][41][42]. No evidence of covalent bonding of the glycerol with components of the inserts was observed, however, it may be associated by hydrogen bonding with the polymer molecules.…”

Section: Discussioncontrasting

confidence: 64%

Biodegradable hybrid polymeric membranes for ocular drug delivery

Jain¹,

Carvalho²,

Banerjee³

2010

Acta Biomaterialia

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Section: Discussioncontrasting

confidence: 64%

Biodegradable hybrid polymeric membranes for ocular drug delivery

Jain¹,

Carvalho²,

Banerjee³

2010

Acta Biomaterialia

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“…The folding endurance of ocular films was determined by the number of folds at a specific single place required to break the film into two parts. The thickness of the recovered films was measured using screw gauze [9]. After performing the initial settings the film was placed on the anvil such that area where the thickness is to be measured lies.…”

Section: Physicochemical Characterization Of Ocular Filmsmentioning

confidence: 99%

Evaluation of Ocular Films of Ofloxacin for Antibacterial Activity

Kumar¹,

Tiwari

Kumar³

2018

Int J App Pharm

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Objective: The current study emphasizes on the treatment of ocular infection with objectives of reducing the frequency of administration, obtaining controlled release and greater therapeutic efficacy of the drug (ofloxacin) using ocular films.Methods: Ocular films were designed by solvent evaporation method containing a different combination of polymers. The folding endurance (mechanical strength) was determined by the number of folds at a specific single place required to break the film into two parts. Thickness was measured using screw gauze. The surface pH was done by pH paper. The percentage moisture absorption was carried out by placing the ocular films in a desiccator containing ammonium chloride. Percentage moisture loss was carried out by placing the ocular films in the desiccator containing anhydrous calcium chloride. in vitro drug release study were carried by using a modified version of franz diffusion cell. Stability study were carried using stability chambers as per ICH guidelines. The antibacterial activity was performed by using male albino rabbits.Results: The thickness and folding endurance of the films were in the range of 44±1.1 to 92±1.8 and 4.5±0.6 to 6.8±0.3, respectively for different formulations. Surface pH was evaluated in the range of 6.6 to 7.2. Percentage moisture absorption and percentage moisture loss were evaluated in the range of 1.17±1.1 to 6.72±1.5 and 0.58±0.9 to 1.23±0.9 respectively. Microbial growth was not observed in any formulation during sterility testing. The drug release for different batch codes PAH, PBE, PCP, PDC, PEEH, and PFEC was found to be 96.2, 56.9, 93.4, 94.5, 98.4 and 95.9 % respectively up to 12 h. Ocular films of batch code PEEH was optimized for maximum drug release (98.4%). The antibacterial effect was noted periodically (01 to 05 d) after administration of sterile formulation in the treated eyes vs. control eyes of each rabbit. The optimized batch PEEH of ocular films reduced the infection and redness completely within 3 d in a single dose.Conclusion: The optimized formulation would be able to offer benefits such as increased residence time, prolonged drug release, reduced frequency of administration and improved patient compliance with complete removal of inflammation and redness from the cul-de-sac.

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“…The implants were sterilized by exposing them to UV radiation at 254 nm for 30 min (24). The direct inoculation method, as described in the Brazilian Pharmacopeia (22), was used to test the sterility of the irradiated implants.…”

Section: Sterilization and Sterility Test For Implantsmentioning

confidence: 99%

Development and Evaluation of Sustained-Release Etoposide-Loaded Poly(ε-Caprolactone) Implants

et al. 2013

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Poly(ε-caprolactone) implants containing etoposide, an important chemotherapeutic agent and topoisomerase II inhibitor, were fabricated by a melt method and characterized in terms of content uniformity, morphology, drug physical state, and sterility. In vitro and in vivo drug release from the implants was also evaluated. The cytotoxic activity of implants against HeLa cells was studied. The short-term tolerance of the implants was investigated after subcutaneous implantation in mice. The original chemical structure of etoposide was preserved after incorporation into the polymeric matrix, in which the drug was dispersed uniformly. Etoposide was present in crystalline form in the polymeric implant. In vitro release study showed prolonged and controlled release of etoposide, which showed cytotoxicity activity against HeLa cells. After implantation, good correlation between in vitro and in vivo drug release was found. The implants demonstrated good short-term tolerance in mice. These results tend to show that etoposide-loaded implants could be potentially applied as a local etoposide delivery system.

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Formulation and evaluation of drug-free ophthalmic films prepared by using various synthetic polymers

Cited by 14 publications

References 2 publications

Biodegradable hybrid polymeric membranes for ocular drug delivery

Biodegradable hybrid polymeric membranes for ocular drug delivery

Evaluation of Ocular Films of Ofloxacin for Antibacterial Activity

Development and Evaluation of Sustained-Release Etoposide-Loaded Poly(ε-Caprolactone) Implants

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